Patron, Maria ORCID: 0000-0003-1165-597X, Granatiero, Veronica ORCID: 0000-0003-2440-5144, Espino, Javier ORCID: 0000-0002-8549-9343, Rizzuto, Rosario and De Stefani, Diego ORCID: 0000-0003-3796-8907 (2019). MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake. Cell Death Differ., 26 (1). S. 179 - 196. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5403

Full text not available from this repository.

Abstract

The versatility and universality of Ca2+ as intracellular messenger is guaranteed by the compartmentalization of changes in [Ca2+]. In this context, mitochondrial Ca2+ plays a central role, by regulating both specific organelle functions and global cellular events. This versatility is also guaranteed by a cell type-specific Ca2+ signaling toolkit controlling specific cellular functions. Accordingly, mitochondrial Ca2+ uptake is mediated by a multimolecular structure, the MCU complex, which differs among various tissues. Its activity is indeed controlled by different components that cooperate to modulate specific channeling properties. We here investigate the role of MICU3, an EF-hand containing protein expressed at high levels, especially in brain. We show that MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca2+ uptake. Silencing of MICU3 in primary cortical neurons impairs Ca2+ signals elicited by synaptic activity, thus suggesting a specific role in regulating neuronal function.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Patron, MariaUNSPECIFIEDorcid.org/0000-0003-1165-597XUNSPECIFIED
Granatiero, VeronicaUNSPECIFIEDorcid.org/0000-0003-2440-5144UNSPECIFIED
Espino, JavierUNSPECIFIEDorcid.org/0000-0002-8549-9343UNSPECIFIED
Rizzuto, RosarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Stefani, DiegoUNSPECIFIEDorcid.org/0000-0003-3796-8907UNSPECIFIED
URN: urn:nbn:de:hbz:38-140886
DOI: 10.1038/s41418-018-0113-8
Journal or Publication Title: Cell Death Differ.
Volume: 26
Number: 1
Page Range: S. 179 - 196
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5403
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CA2+ UPTAKE; ESSENTIAL COMPONENT; MOLECULAR DETERMINANTS; UNIPORTER; MCU; PROTEIN; LETM1; INACTIVATION; GATEKEEPER; METABOLISMMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14088

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item