Universität zu Köln

Klapdor, Ruediger, Woelber, Linn, Hanker, Lars, Schmalfeldt, Barbara, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Jueckstock, Julia, Hilpert, Felix, de Gregorio, Nikolaus, Hillemanns, Peter, Fuerst, Sophie Teresa and Mahner, Sven (2019). Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study. Gynecol. Oncol., 154 (3). S. 565 - 571. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-6859

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Abstract

Background. Lymph node (LN) metastasis is the most important prognostic factor in primary vulvar cancer. Assessing risk factors for the incidence and extent of LN metastases may help to select the optimal treatment strategy for each individual patient. Methods. In a subgroup analysis of the large multicenter AGO-CaRE-1 study we included all patients treated with radical groin dissection. Univariate and multivariate regression analyses were performed in order to detect factors associated with the prevalence and extent of nodal involvement. Results. In total, 1162 patients were analyzed. Univariate analyses detected age, ECOG as well as multiple tumor characteristics such as FIGO stage, grading, depth of invasion, tumor diameter, and (lymph)vascular space invasion to be related with the prevalence of LN metastases. Interestingly, only tumor stage, tumor diameter and depth of infiltration were found to be significantly associated with the number of LN metastases. In multivariate analysis, age (OR 1.03), lymphvascular space invasion (OR 4.97), tumor stage (OR 2.22) and depth of infiltration (OR 1.08) showed an association with the prevalence of LN metastases. Regarding the number of metastatic LNs, only tumor stage (OR 221) or, if excluded, tumor diameter (OR 1.02) were tested significant. Conclusion. This large analysis of the multicenter AGO-CaRE-1-study identified lymphvascular space invasion, tumor stage, and depth of infiltration as factors with the strongest association regarding the prevalence of LN metastasis. Interestingly, tumor stage or, if excluded, tumor diameter were the only factors associated with the prevalence as well as the extent of LN metastases. (C) 2019 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klapdor, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Woelber, Linn UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanker, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalfeldt, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Canzler, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Fehm, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Luyten, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellriegel, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kosse, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiss, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Hantschmann, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tanner, Berno UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfisterer, Jacobus UNSPECIFIED UNSPECIFIED UNSPECIFIED Jueckstock, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilpert, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED de Gregorio, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillemanns, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuerst, Sophie Teresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahner, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142743
DOI:	10.1016/j.ygyno.2019.06.013
Journal or Publication Title:	Gynecol. Oncol.
Volume:	154
Number:	3
Page Range:	S. 565 - 571
Date:	2019
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-6859
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; PROGNOSTIC-FACTORS; DISSECTION; RECURRENCE; SURVIVAL; PATTERNS Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14274