Niether, Doreen and Wiegand, Simone ORCID: 0000-0001-6333-1956 (2019). Thermodiffusion and hydrolysis of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). Eur. Phys. J. E, 42 (9). NEW YORK: SPRINGER. ISSN 1292-895X

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Abstract

Presently, microfluidic traps are designed mimicking the environment of hydrothermal pores, where a combination of thermophoresis and convection leads to accumulation so that high concentrations of organic matter can be reached. Such a setup is interesting in the context of the origin of life to observe accumulation and possible further synthesis of small organic molecules or prebiotic molecules such as nucleotides or RNA-fragments, but could also be used to replicate DNA-strands. The addition of coupling agents for the activation of carboxyl or phosphate groups such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and EDC-hydrochloride (EDC-HCl) is necessary in order to speed up the process. This work characterizes the thermophoretic properties of EDC and EDC-HCl needed to optimize the design of the traps. At p H 4-6 spontaneous hydrolysis of EDC is observed, which also leads to a neutralisation of the p H. In order to evaluate the thermodiffusion measurements the rate constants were measured at 23 and C and the activation energy of the hydrolysis calculated.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Niether, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiegand, SimoneUNSPECIFIEDorcid.org/0000-0001-6333-1956UNSPECIFIED
URN: urn:nbn:de:hbz:38-143030
DOI: 10.1140/epje/i2019-11880-1
Journal or Publication Title: Eur. Phys. J. E
Volume: 42
Number: 9
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1292-895X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Polymer ScienceMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14303

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