Universität zu Köln

Guenal, Sueleyman, Hardman, Rebecca, Kopriva, Stanislav ORCID: 0000-0002-7416-6551 and Mueller, Jonathan Wolf ORCID: 0000-0003-1212-189X (2019). Sulfation pathways from red to green. J. Biol. Chem., 294 (33). S. 12293 - 12313. ROCKVILLE: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 1083-351X

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Abstract

Sulfur is present in the amino acids cysteine and methionine and in a large range of essential coenzymes and cofactors and is therefore essential for all organisms. It is also a constituent of sulfate esters in proteins, carbohydrates, and numerous cellular metabolites. The sulfation and desulfation reactions modifying a variety of different substrates are commonly known as sulfation pathways. Although relatively little is known about the function of most sulfated metabolites, the synthesis of activated sulfate used in sulfation pathways is essential in both animal and plant kingdoms. In humans, mutations in the genes encoding the sulfation pathway enzymes underlie a number of developmental aberrations, and in flies and worms, their loss-of-function is fatal. In plants, a lower capacity for synthesizing activated sulfate for sulfation reactions results in dwarfism, and a complete loss of activated sulfate synthesis is also lethal. Here, we review the similarities and differences in sulfation pathways and associated processes in animals and plants, and we point out how they diverge from bacteria and yeast. We highlight the open questions concerning localization, regulation, and importance of sulfation pathways in both kingdoms and the ways in which findings from these red and green experimental systems may help reciprocally address questions specific to each of the systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Guenal, Sueleyman UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardman, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopriva, Stanislav UNSPECIFIED orcid.org/0000-0002-7416-6551 UNSPECIFIED Mueller, Jonathan Wolf UNSPECIFIED orcid.org/0000-0003-1212-189X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144196
DOI:	10.1074/jbc.REV119.007422
Journal or Publication Title:	J. Biol. Chem.
Volume:	294
Number:	33
Page Range:	S. 12293 - 12313
Date:	2019
Publisher:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Place of Publication:	ROCKVILLE
ISSN:	1083-351X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FORMYLGLYCINE-GENERATING ENZYME; ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE; INOSITOL POLYPHOSPHATE 1-PHOSPHATASE; CYTOSOLIC SULFOTRANSFERASE 1A1; ATP SULFURYLASE; STEROID SULFATASE; ARABIDOPSIS-THALIANA; NATURAL VARIATION; STRUCTURAL BASIS; PHOSPHOADENOSINE 5'-PHOSPHOSULFATE Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14419