Universität zu Köln

Domroese, Christian M. and Mallmann, Peter (2019). Innovative treatments for metastasized cervical cancer. Gynakologe, 52 (8). S. 601 - 605. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393

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Abstract

Surgery, radiotherapy, and chemotherapy are the common treatment options for palliative therapy of metastatic cervical cancer. They are currently supplemented with innovative therapeutic options and will continue to be so the future. The vascular endothelial growth factor (VEGF) antibody bevacizumab-already approved for treatment of cervical cancer-interacts with tumor neoangiogenesis and can complement the effects of classical chemotherapy. At present, innovative therapies include drugs that do not attack the tumor itself but rather affect the immune system, such as immune checkpoint inhibitors. By inhibiting programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1), e.g., with pembrolizumab, nivolumab, atezolizumab, or avelumab, T-cells and thus the own immune defense can be activated. Another immune checkpoint inhibitor is the anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) antibody (ipilimumab). Other targeted therapies include tyrosine kinase inhibitors, which are also being studied in the treatment of cervical cancer. In addition to the successful prophylactic vaccination against HPV, therapeutic vaccinations also represent a promising innovative therapeutic approach for the future treatment of metastatic cervical cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Domroese, Christian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145746
DOI:	10.1007/s00129-019-4457-z
Journal or Publication Title:	Gynakologe
Volume:	52
Number:	8
Page Range:	S. 601 - 605
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0393
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPRESSION; CHEMOTHERAPY; RECURRENT; PD-L1 Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14574