Fangauf, Stella V., Meyer, Thomas, Albus, Christian, Binder, Lutz, Deter, Hans-Christian, Ladwig, Karl-Heinz, Michal, Matthias, Ronel, Joram, Rothenberger, Aribert, Soellner, Wolfgang, Wachter, Rolf, Weber, Cora S., Herrmann-Lingen, Christoph, Koepsel, Andrea, Kronfeldt, Daniela, Orth-Gomer, Kristina, Pieske, Burkert, Rudat, Miriam, Siebenhuener, Sabine, Nauheim, Bad, Jordan, Jochen, Hellmich, Martin, Lambertus, Frank, Paulus, Ursula, Stoehr, Andreas, Vitinius, Frank, Wolff-Stephan, Silvia, Israel, Matthias, Mueck-Weymann, Michael, Petrowski, Katja, Bursch, Stephanie, Fritzsche, Kurt, Bosbach, Alexandra, Jamrozinski, Katja, Lackschewitz, Halina, Stoetzel, Regina, Maelzig, Ulrike, de Zwaan, Martina, Krauth, Christian, Reichert, Cornelia, Schwandt, Barbara, Waller, Christiane, Hain, Bernhard, Juenger, Jana, Schultz, Jobst-Hendrik, Beutel, Manfred E., Wiltink, Joerg, Henningsen, Christina, Behnisch, Ruediger and Kraiss, Anita (2019). Longitudinal relationship between B-type natriuretic peptide and anxiety in coronary heart disease patients with depression. J. Psychosomat. Res., 123. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1879-1360

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Abstract

Objective: Patients with coronary heart disease (CHD) suffer from physical limitations, but also from psychological distress. Natriuretic peptides may be involved in the neurobiological processes that modulate psychological adaptation, as they are increased in heart disease and seem to have an anxiolytic-like function. Longitudinal data on this association are scarce. Methods: To assess the relationship between NT-proBNP and anxiety (Hospital Anxiety and Depression Scale (HADS)), we used secondary data from a multicenter trial from baseline to 24 months. Patients (N = 308, 80.8% male, mean age 60.1 years) had stable CHD and moderate levels of depression (HADS >= 8). Results: Multiple linear regression adjusted for age, sex, BMI, and physical functioning revealed NT-proBNP as a significant predictor for anxiety at baseline, 1, 6, 12, 18, and 24 months (all p < .05). Linear mixed model analysis with the six anxiety measures as level-1 variable and NT-proBNP as fixed factor revealed a significant time*NT-proBNP interaction (t(1535.99) = -2.669, p = .01) as well as a significant time*NT-proBNP*sex-interaction (1(1535.99) = 3.277, p = .001), when NT-proBNP was dichotomized into lowest vs. the three highest quartiles. Conclusion: Our results indicate a stable negative association of baseline NT-proBNP with anxiety over two years. In men and women, different pathways modulating this relationship appear to be in effect. Female patients with very low NT-proBNP levels, despite their cardiac disease, show persistently higher levels of anxiety compared to women with higher levels of NT-proBNP and compared to men.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fangauf, Stella V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Binder, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deter, Hans-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ladwig, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michal, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ronel, JoramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothenberger, AribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soellner, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachter, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Cora S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrmann-Lingen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koepsel, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronfeldt, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orth-Gomer, KristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieske, BurkertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudat, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebenhuener, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nauheim, BadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambertus, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paulus, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoehr, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vitinius, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff-Stephan, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Israel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueck-Weymann, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrowski, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bursch, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fritzsche, KurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosbach, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamrozinski, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lackschewitz, HalinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoetzel, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maelzig, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Zwaan, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krauth, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichert, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwandt, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waller, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hain, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juenger, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultz, Jobst-HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beutel, Manfred E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltink, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henningsen, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behnisch, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraiss, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-145782
DOI: 10.1016/j.jpsychores.2019.05.006
Journal or Publication Title: J. Psychosomat. Res.
Volume: 123
Date: 2019
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication: OXFORD
ISSN: 1879-1360
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEPWISE PSYCHOTHERAPY INTERVENTION; ARTERY-DISEASE; RANDOMIZED-TRIAL; REDUCING RISK; SPIRR-CAD; ASSOCIATIONS; MULTICENTER; SEVERITY; FAILURE; SYSTEMMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14578

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