Fischer, Michael R., Schermann, Anja I., Twelkmeyer, Trix, Lorenz, Beate, Wegner, Joanna, Jonuleit, Helmut and von Stebut, Esther (2019). Humanized mice in cutaneous leishmaniasis-Suitability analysis of human PBMC transfer into immunodeficient mice. Exp. Dermatol., 28 (9). S. 1087 - 1091. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Humanized mice represent a suitable preclinical test system for example therapeutic interventions in various disease settings, including infections. Here, we intended to establish such system for cutaneous leishmaniasis by infecting T, B and NK cell-deficient mice adoptively transferred with human peripheral blood mononuclear cells (PBMC). L major infection led to the establishment of parasite lesions harbouring viable parasites and human T cells, but parasite elimination was not seen due to a species-specific activity of T cell-derived human IFN gamma. In addition, up to 50% of infected mice succumbed to severe graft-versus-host disease. In summary, even though long-term disease outcome assessments are impossible, this model of humanized mice can be used for studying lesion development and generation of oligoclonal anti-parasite human T cell responses in vivo.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fischer, Michael R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schermann, Anja I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Twelkmeyer, TrixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenz, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wegner, JoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jonuleit, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Stebut, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-145938
DOI: 10.1111/exd.13999
Journal or Publication Title: Exp. Dermatol.
Volume: 28
Number: 9
Page Range: S. 1087 - 1091
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-0625
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOUSE MODEL; INFECTIONMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14593

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