Universität zu Köln

Eghbalzadeh, Kaveh, Kuhn, Elmar W., Sabashnikov, Anton, Weber, Carolyn, Rahmanian, Parwis Baradaran, Siedek, Florian, Mauri, Victor, Rudolph, Tanja, Baldus, Stephan, Madershahian, Navid and Wahlers, Thorsten C. (2019). Latest Generation of Balloon-Expandable Valve, the Edwards Sapien 3 Valve: Less Paravalvular Regurgitation but Higher Transvalvular Pressure Gradients. Thorac. Cardiovasc. Surg., 67 (4). S. 236 - 243. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-1902

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Abstract

Background The latest generation of balloon-expandable valve, the Edwards Sapien 3 valve (S3V), was designed to reduce paravalvular regurgitation (PVR). We retrospectively compared S3V with Edwards Sapien XT valve (SXTV) with regard to postprocedural transvalvular pressure gradients (PGs). Methods Analysis of 152 patients receiving SXTV and 125 patients receiving S3V between February 2009 and April 2015 was performed. Transvalvular PGs and the incidence and extent of aortic regurgitation (AR) were compared postprocedurally by echocardiography for each valve size. Results Postprocedurally, mean PGs for the 23mm valves were 10.95.3 versus 13.9 +/- 5.1 ( p =0.017), whereas maximum PGs were 19.9 +/- 8.3 versus 26.1 +/- 10.4mm Hg ( p =0.005) in SXTV and S3V patients, respectively. For the 26mm valves, gradients were also significantly higher in S3V patients (mean PG: 11.6 +/- 4.9 vs. 9.2 +/- 4.2 [ p =0.004]; maximum PG: 23.0 +/- 10.1 vs. 17.2 +/- 7.4mm Hg [ p <0.001]). Analysis revealed no significant differences in postprocedural transvalvular PGs for 29mm valves (mean PG of 9.3 +/- 3.9 and 11.2 +/- 4.3mm Hg [ p =ns] and maximum PG of 17.5 +/- 7.2 vs. 20.9 +/- 6.8mm Hg [ p =ns]) between SXTV and S3V groups, respectively. With respect to PVR, the incidence of AR was significantly lower in S3V group ( p =0.001). Conclusion S3V shows lower incidence of PVR; however, it is associated with significantly higher postprocedural transvalvular PGs for 23 and 26mm valve sizes. These data might contribute to the scientific discussion, especially with respect to prosthesis selection in individual patients with small annular dimension.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eghbalzadeh, Kaveh UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Elmar W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Carolyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahmanian, Parwis Baradaran UNSPECIFIED UNSPECIFIED UNSPECIFIED Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauri, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Madershahian, Navid UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-146024
DOI:	10.1055/s-0037-1608750
Journal or Publication Title:	Thorac. Cardiovasc. Surg.
Volume:	67
Number:	4
Page Range:	S. 236 - 243
Date:	2019
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-1902
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AORTIC-VALVE; TRANSCATHETER; IMPLANTATION; REPLACEMENT; PROSTHESIS; PREDICTORS; STENOSIS; OUTCOMES Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14602