Universität zu Köln

Marnitz, S., Morgenthaler, J., Kunze, S. and Herter, J. (2019). Radiochemotherapy for the treatment of cervical cancer. Onkologe, 25 (6). S. 543 - 555. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

Primary combined radiochemotherapy is standard in locally advanced and node-positive tumors regardless of stage. The combination of radical hysterectomy and chemoradiotherapy should be avoided. Ovariopexy prior to chemoradiation can significantly reduce the dose to the ovaries and prevent early menopause. In histologically confirmed para-aortic lymph node metastasis, extended field radiation therapy (EFRT) provides excellent local para-aortal control, and half of those affected achieve long-term survival. Neoadjuvant chemotherapy followed by hysterectomy should only be performed within studies. Combination of bevacizumab with paclitaxel-cisplatin or paclitaxel-topotecan combination therapy is the current standard in patients with metastases, progressive disease or locally advanced, nonsurgically treatable disease. As an immunogenic tumor, cervical cancer is also a good target for checkpoint inhibition and other immunotherapeutic agents.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marnitz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morgenthaler, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunze, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-147099
DOI:	10.1007/s00761-019-0575-4
Journal or Publication Title:	Onkologe
Volume:	25
Number:	6
Page Range:	S. 543 - 555
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTENDED-FIELD IRRADIATION; RADICAL SURGERY; NEOADJUVANT CHEMOTHERAPY; CHEMORADIATION THERAPY; CLINICAL-TRIAL; STAGE-IB; RADIOTHERAPY; MULTICENTER; METASTASES; MELANOMA Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14709