Thangarajah, Fabinshy, Morgenstern, Bernd, Pahmeyer, Caroline, Schiffmann, Lars Mortimer, Puppe, Julian, Mallmann, Peter, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Buettner, Reinhard, Alidousty, Christina, Holz, Barbara, Scheel, Andreas H. and Schultheis, Anne Maria (2019). Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva. J. Cancer Res. Clin. Oncol., 145 (6). S. 1651 - 1661. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

PurposeSquamous cell carcinoma of the vulva (SQCV) is the fifth most common cancer in women and accounts for about 5% of all genital cancers in women. The PD-L1 signaling pathway is activated in many malignant neoplasms and its blockade enhances anti-cancer immunity. The aim of our study was to examine the protein expression of PD-L1 and PD-1 in squamous cell cancer of the vulva, its correlations with clinicopathologic features and prognostic value.MethodsPatients with SQCV treated in one institution were used for the analyses. PD-L1 immunohistochemistry was performed on 4 mu m-thick section of the respective FFPE tissue blocks using the 28-8 antibody. PD-L1 scoring was performed separately for tumour cells (TC) and tumour associated immune cells. DNA was extracted to determine HPV status. Kaplan-Meier estimates for disease-free-survival and overall-survival were calculated and compared by log-rank test.ResultsPD-L1 expression in tumour cells could be observed in 32.9% of the patients. The expression of PD-L1 in peritumoural immune cells was confirmed in 91.4% of the patients. A significant correlation between PD-L1 expression in tumour cells and tumour stage was detected (p=0.007). PD-L1 expression was independent from HPV status. Using the log-rank test we could not prove any significant differences in disease-free survival (p=0.434) and overall survival (p=0.858). Regression analysis showed that nodal status is a predictive factor of survival (p<0.001).ConclusionThe present study showed that a relevant amount of patients with squamous cell cancer of the vulva express PD-L1 in both, tumour cells and tumour-associated immune cells. Furthermore, the significant correlation of PD-L1 expression in TCs with tumour stage indicated the clinical impact of PD-L1 expression during tumour development. These data indicate that SQCV might be amenable to immune checkpoint-inhibition and constitute a rational for the future clinical trials.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Thangarajah, FabinshyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgenstern, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pahmeyer, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiffmann, Lars MortimerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puppe, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamacher, StefanieUNSPECIFIEDorcid.org/0000-0003-2158-9101UNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alidousty, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holz, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheel, Andreas H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultheis, Anne MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-147250
DOI: 10.1007/s00432-019-02915-1
Journal or Publication Title: J. Cancer Res. Clin. Oncol.
Volume: 145
Number: 6
Page Range: S. 1651 - 1661
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1335
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTRAEPITHELIAL NEOPLASIA; CARCINOMA; NIVOLUMAB; BLOCKADE; SAFETY; IMMUNOTHERAPY; BIOMARKERS; ANTIBODY; B7-H1; ASSAYMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14725

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