Universität zu Köln

Stegmann, Sarah, Werner, Jan-Michael, Kuhl, Saskia, Roehn, Gabriele, Krischek, Boris, Stavrinou, Pantelis, Goldbrunner, Roland and Timmer, Marco (2019). Death Receptor 6 (DR6) Is Overexpressed in Astrocytomas. Anticancer Res., 39 (5). S. 2299 - 2307. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background/Aim: Death receptor 6 (DR6) is a member of the tumor necrosis factor receptor superfamily. The expression of DR6 is elevated in different kinds of tumors including ovarian, breast cancer and adult sarcoma. In these tumors, the receptor may be handled as a new diagnostic and prognostic marker. Thus, we investigated the expression of DR6 in gliomas. Materials and Methods: Tumor and control tissues were extracted during neurosurgery and grouped according to the WHO classification. DR6 expression was investigated in low- and high-grade gliomas PCR (n=70), immunofluorescence staining (n=33) and western blot (n=58). Additional analysis of TCGA-data was performed to assess the general alteration of DR6 in cancer and influence of IDH-mutation on DR6 expression in gliomas. Results: The expression of DR6 was significantly enhanced in gliomas (p<0.05). It showed a trend towards rising expression with increasing malignancy of the tumor. Chemotherapy treatment could have an influence on DR6 expression. Conclusion: In our investigation, DR6 acts as a potential suitable diagnostic marker for gliomas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stegmann, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jan-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhl, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Roehn, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149167
DOI:	10.21873/anticanres.13346
Journal or Publication Title:	Anticancer Res.
Volume:	39
Number:	5
Page Range:	S. 2299 - 2307
Date:	2019
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPRESSION; TUMORS; IDENTIFICATION; BIOMARKERS; BRAIN Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14916