Universität zu Köln

Dietmaier, W., Buettner, R. and Rueschoff, J. (2019). Microsatellite instability. Review of methods and applications. Pathologe, 40 (3). S. 313 - 328. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1963

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Abstract

After introduction of the Bethesda microsatellite test panel demonstration of microsatellite instability (MSI) and/or loss of mismatch repair proteins (MMRD) was primarily used as amarker for cancer predisposition of Lynch syndrome (LS, previous: HNPCC). Nowadays MSI/MMRD has become an important biomarker to predict therapy response to checkpoint immunotherapies. MSI can be determined either by polymerase chain reaction (PCR)-based technologies with or without specification of fragment sizes or next generation sequencing (NGS) methods. Depending on the individual tumor entities, these test methods are used differently. Currently, MSI/MMRD is atumor biomarker which covers abroad spectrum of indications in tumor pathology, especially in colorectal, endometrial and gastric cancer. In advanced carcinomas, MSI is an established predictor of therapy response to checkpoint-directed immunotherapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dietmaier, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueschoff, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149330
DOI:	10.1007/s00292-019-0610-7
Journal or Publication Title:	Pathologe
Volume:	40
Number:	3
Page Range:	S. 313 - 328
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1963
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MISMATCH REPAIR-DEFICIENCY; COLORECTAL-CANCER PATIENTS; LYNCH-SYNDROME; TUMORS; IMMUNOHISTOCHEMISTRY; SURVIVAL Multiple languages Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14933