Universität zu Köln

Marnitz, S. (2019). Modern radiotherapy of vulvar cancer. Onkologe, 25 (5). S. 433 - 437. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

Full text not available from this repository.

Abstract

BackgroundOver the last 20years the oncological results in the treatment of vulvar cancer have not been improved. Due to a lack of evidence from randomized studies many aspects of treatment are unclear and controversial. From aradio-oncological perspective the aims of treatment are the avoidance of local and locoregional recurrences, improvement of organ and function preservation within the framework of the interdisciplinary treatment concept and avoidance of unnecessary toxicity.MethodAliterature search was carried out and asystematic presentation of the current treatment standards in the radio-oncological treatment of vulvar cancer is given.ResultsTumor-infested resection margins necessitate alocal follow-up resection or, if this is not possible or functionally unfavorable, postoperative (chemo)radiotherapy. The current German guidelines recommend aresection of at least 3mm into healthy tissue. The prevention of inguinal recurrences improves the disease-free survival. The frequently carried out practice of pelvic irradiation is overtreatment in approximately 70%, even for patients with positive inguinal lymph nodes. In this case areevaluation has become established for avoidance of unnecessary toxicity. The current German guidelines recommend asurgical staging of the pelvis and pelvic irradiation only in cases of positive lymph nodes.ConclusionTopics of discussion and future reevaluation are the value of simultaneous chemotherapy, neoadjuvant versus primary chemoradiotherapy, the optimal radiosensitizing substance and the optimal irradiation dosage in primary treatment. An interdisciplinary approach represents an indispensable prerequisite for an optimal treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marnitz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-149988
DOI:	10.1007/s00761-019-0562-9
Journal or Publication Title:	Onkologe
Volume:	25
Number:	5
Page Range:	S. 433 - 437
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; PELVIC NODE RESECTION; RADIATION-THERAPY; ADJUVANT RADIATION; GROIN; WOMEN Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14998