Universität zu Köln

Phipps, Elizabeth A., Thadhani, Ravi, Benzing, Thomas and Karumanchi, S. Ananth (2019). Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat. Rev. Nephrol., 15 (5). S. 275 - 290. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1759-507X

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Abstract

Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal and fetal morbidity and mortality. The disease presents with new-onset hypertension and often proteinuria in the mother, which can progress to multi-organ dysfunction, including hepatic, renal and cerebral disease, if the fetus and placenta are not delivered. Maternal endothelial dysfunction due to circulating factors of fetal origin from the placenta is a hallmark of pre-eclampsia. Risk factors for the disease include maternal comorbidities, such as chronic kidney disease, hypertension and obesity; a family history of pre-eclampsia, nulliparity or multiple pregnancies; and previous pre-eclampsia or intrauterine fetal growth restriction. In the past decade, the discovery and characterization of novel antiangiogenic pathways have been particularly impactful both in increasing understanding of the disease pathophysiology and in directing predictive and therapeutic efforts. In this Review, we discuss the pathogenic role of antiangiogenic proteins released by the placenta in the development of pre-eclampsia and review novel therapeutic strategies directed at restoring the angiogenic imbalance observed during pre-eclampsia. We also highlight other notable advances in the field, including the identification of long-term maternal and fetal risks conferred by pre-eclampsia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Phipps, Elizabeth A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thadhani, Ravi UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Karumanchi, S. Ananth UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-150064
DOI:	10.1038/s41581-019-0119-6
Journal or Publication Title:	Nat. Rev. Nephrol.
Volume:	15
Number:	5
Page Range:	S. 275 - 290
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1759-507X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL-GROWTH-FACTOR; TYROSINE KINASE 1; ANTI-ANGIOGENIC FACTORS; CIRCULATING ANTIANGIOGENIC FACTORS; RECEPTOR AGONISTIC AUTOANTIBODIES; CATECHOL-O-METHYLTRANSFERASE; ENDOPLASMIC-RETICULUM STRESS; REDUCED UTERINE PERFUSION; EARLY-ONSET PREECLAMPSIA; SOLUBLE ENDOGLIN Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15006