Universität zu Köln

Caskey, Marina, Klein, Florian and Nussenzweig, Michel C. (2019). Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic. Nat. Med., 25 (4). S. 547 - 554. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-170X

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Abstract

Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART interruption almost invariably leads to rebound viremia in infected individuals due to a long-lived latent reservoir of integrated proviruses. Therefore, ART must be administered on a life-long basis. Here we review recent preclinical and clinical studies suggesting that immunotherapy may be an alternative or an adjuvant to ART because, in addition to preventing new infections, anti-HIV-1 antibodies clear the virus, directly kill infected cells and produce immune complexes that can enhance host immunity to the virus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caskey, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nussenzweig, Michel C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-152520
DOI:	10.1038/s41591-019-0412-8
Journal or Publication Title:	Nat. Med.
Volume:	25
Number:	4
Page Range:	S. 547 - 554
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1546-170X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS; MUCOSAL SHIV CHALLENGE; PASSIVE TRANSFER; IN-VITRO; IMPROVES PROTECTION; IMMUNE-RESPONSES; LATENT RESERVOIR; HIV-1 INFECTION; DURABLE CONTROL; PHASE-I Multiple languages Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15252