Universität zu Köln

Johnson, Sarah, Schiffner, Julia, Freundl, Guenter, Bachmann, Nina and Gnoth, Christian (2019). Luteinising hormone profiles in conception and non-conception natural cycles. Eur. J. Contracept. Reprod. Health Care, 24 (2). S. 140 - 148. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-0782

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Abstract

Objective: The aim of this study was to assess whether luteinising hormone (LH) surge characteristics influenced the likelihood of conceiving naturally.Methods: This was a single-cycle, home-based, observational, case-controlled study. Volunteers collected daily urine samples for one menstrual cycle. LH was measured and the basal levels, surge day, peak day, peak concentration and magnitude of LH surges were examined. Predictive models using sociodemographic data, LH surge characteristics, and sociodemographic data combined with LH profile properties, were evaluated.Results: The surge profile did not differ between cycles with early or late ovulation and was not affected by age or body mass index (BMI). The mean LH surge day was day 16 for both groups. Mean LH surge and concentrations did not differ between groups (surge concentration 54.8IU/l vs. 58.2IU/l and peak concentration 82.0IU/l vs. 81.6IU/l for pregnant vs. non-pregnant volunteers, respectively). Non-pregnant volunteers were more likely, however, to have a raised or a reduced basal LH on day 6 or have an atypical LH profile. Sociodemographic characteristics were significant predictors of pregnancy, and sociodemographic variable-based models had the greatest predictive ability for conception, providing up to 65% predictive accuracy.Conclusions: Sociodemographic variables can be used to predict the likelihood of a woman conceiving naturally. Provided an LH surge is present, its profile does not relate to the likelihood of spontaneous pregnancy. The conception rate was significantly lower, however, in women with elevated or reduced basal levels of LH, suggesting that follicular maturation needs an optimal basal level of LH in natural conception cycles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Johnson, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Freundl, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gnoth, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-154258
DOI:	10.1080/13625187.2019.1590697
Journal or Publication Title:	Eur. J. Contracept. Reprod. Health Care
Volume:	24
Number:	2
Page Range:	S. 140 - 148
Date:	2019
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-0782
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MENSTRUAL-CYCLE; OOCYTE MATURATION; FOLLICULAR PHASE; OVULATION; URINARY; WOMEN; LH; PREGNANCY; IMPACT; SURGE Multiple languages Public, Environmental & Occupational Health; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15425