Koethe, Dagmar ORCID: 0000-0002-8324-6756, Pahlisch, Franziska, Hellmich, Martin, Rohleder, Cathrin ORCID: 0000-0002-3559-1846, Mueller, Juliane K., Meyer-Lindenberg, Andreas, Torrey, E. Fuller, Piomelli, Daniele ORCID: 0000-0002-2983-774X and Leweke, F. Markus ORCID: 0000-0002-8163-195X (2019). Familial abnormalities of endocannabinoid signaling in schizophrenia. World J. Biol. Psychiatry, 20 (2). S. 117 - 126. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412
Full text not available from this repository.Abstract
Objectives: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. Methods: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits. Results: Twin pairs discordant for schizophrenia or bipolar disorder had significantly higher levels of anandamide and palmitoylethanolamide compared to healthy twins (both P < 0.002). Non-affected twins discordant for schizophrenia, who developed a psychotic disorder within 5 years follow-up showed lower anandamide (P = 0.042) and 2-arachidonoyl-sn-glycerol levels (P = 0.049) than twins who remained healthy. Conclusions: We suggest that the protective upregulation of endocannabinoid signalling reflects either a hereditary trait or mirrors a modulating response to genetically influenced cerebral function involving, e.g., other neurotransmitters or energy metabolism.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||
Creators: |
|
||||||||||||||||||||||||||||||||||||||||
URN: | urn:nbn:de:hbz:38-156827 | ||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1080/15622975.2018.1449966 | ||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | World J. Biol. Psychiatry | ||||||||||||||||||||||||||||||||||||||||
Volume: | 20 | ||||||||||||||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 117 - 126 | ||||||||||||||||||||||||||||||||||||||||
Date: | 2019 | ||||||||||||||||||||||||||||||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||||||||||||||||||||||||||||||
Place of Publication: | ABINGDON | ||||||||||||||||||||||||||||||||||||||||
ISSN: | 1814-1412 | ||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||||||||||||||||||||||||||
Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/15682 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |