Wojtala, Jennifer, Heber, Ines Ann, Neuser, Petra, Heller, Julia, Kalbe, Elke, Rehberg, Sarah P., Storch, Alexander, Linse, Katharina, Schneider, Christine, Graeber, Susanne, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rudiger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Guenther, Mollenhauer, Brit, Trenkwalder, Claudia, Liepelt-Scarfone, Inga, Spottke, Annika, Roeske, Sandra, Wuellner, Ullrich, Wittchen, Hans-Ulrich, Riedel, Oliver, Dodel, Richard, Schulz, Joerg B. and Reetz, Kathrin (2019). Cognitive decline in Parkinson's disease: the impact of the motor phenotype on cognition. J. Neurol. Neurosurg. Psychiatry, 90 (2). S. 171 - 180. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

Full text not available from this repository.

Abstract

Objectives Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia. The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. Methods Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome. Analyses were performed for all patients and for each diagnostic group separately, controlling for age, gender, education and disease duration. Results Compared with the tremor-dominant phenotype, akinetic-rigid patients performed worse in executive functions such as working memory (Wechsler Memory Scale-Revised backward; p= 0.012), formallexical word fluency (p= 0.043), card sorting (p= 0.006), attention (Trail Making Test version A; p= 0.024) and visuospatial abilities (Leistungsprufungssystem test 9; p= 0.006). Akinetic-rigid neuropsychological test scores for the executive and attentive domain correlated negatively with non-tremor motor scores. Covariate-adjusted binary logistic regression analyses showed significant odds for PD-mild cognitive impairment for not-determined as compared with tremor-dominant (OR= 3.198) and akinetic-rigid PD (OR= 2.059). The odds for PD-dementia were significant for akinetic-rigid as compared with tremor-dominant phenotype (OR= 8.314). Conclusion The three motor phenotypes of PD differ in cognitive performance, showing that cognitive deficits seem to be less severe in tremor-dominant PD. While these data are cross-sectional, longitudinal data are needed to shed more light on these differential findings.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wojtala, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heber, Ines AnnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuser, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heller, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rehberg, Sarah P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linse, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeber, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dams, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzer-Geldsetzer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker-Roggendorf, RudigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberschmidt, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baudrexel, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, NeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuentherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuellner, UllrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Joerg B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reetz, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-157013
DOI: 10.1136/jnnp-2018-319008
Journal or Publication Title: J. Neurol. Neurosurg. Psychiatry
Volume: 90
Number: 2
Page Range: S. 171 - 180
Date: 2019
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-330X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL DIAGNOSTIC-CRITERIA; DEMENTIA; IMPAIRMENT; DEFICITS; SUBTYPE; DOPAMINEMultiple languages
Clinical Neurology; Psychiatry; SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15701

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item