Universität zu Köln

Mellinghoff, Sibylle C., von Bergwelt-Baildon, Michael, Schoesser, Hans A. and Cornely, Oliver A. (2019). A novel approach to candidemia? The potential role of checkpoint inhibition. Med. Mycol., 57 (2). S. 151 - 155. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2709

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Abstract

Infections with Candida spp. cause significant morbidity and mortality despite intensive treatment with antifungal agents. Novel treatment options are urgently needed. Predominately immunocompromised patients are affected. This warrants the conclusion that strengthening host immunity may have the potential to improve outcome. Recent studies imply a potential benefit of checkpoint inhibition reversing hyporesponsiveness of innate and adaptive immunity during invasive fungal infections and invasive candidiasis in particular. We here give a brief overview of first preclinical data in vitro and in vivo and clinical evidence in selected cases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoesser, Hans A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157172
DOI:	10.1093/mmy/myy089
Journal or Publication Title:	Med. Mycol.
Volume:	57
Number:	2
Page Range:	S. 151 - 155
Date:	2019
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2709
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-STREAM INFECTIONS; ATTRIBUTABLE MORTALITY; NOSOCOMIAL CANDIDEMIA; RISK-FACTORS; NIVOLUMAB; PD-1; PEMBROLIZUMAB; CANDIDIASIS; DOCETAXEL; ANTIBODY Multiple languages Infectious Diseases; Mycology; Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15717