Schermer, Bernhard ORCID: 0000-0002-5194-9000 and Benzing, Thomas (2019). Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine? Dtsch. Med. Wochenschr., 144 (4). S. 276 - 282. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

The emergence of genome editing technologies can be regarded as one of the most groundbreaking revolutions in the history of science. Modern genome editing allows the introduction of precise mutations into the genome of virtually all cells and organisms without leaving any additional trace. Undoubtedly, genome editing with CRISPR/Cas9, often casually referred to as genetic scissors, will revolutionize medical research and development. However, at the same time it creates a great need for ethical considerations as it might hold risks for both people and the environment that cannot yet be fully assessed. While genome editing is already well established in laboratory research, clinical applications based on genome editing are close. For the first time, targeted corrections of genetic defects in somatic cells, stem cells as well as in the germ line appear technically feasible. This generates possible future scenarios that urgently require broad ethical and social discussions. Mit einfachen Mitteln lassen sich inzwischen prazise Anderungen am Genom von Zellenund Organismen vornehmen. Die Technologie der Genom-Editierung ist in der Grundlagenforschung bereits fest etabliert - der Einzug der Methodik in die klinische Medizin steht kurz bevor. Diese Revolution der Wissenschaftsgeschichte macht eine breite ethische Diskussion unumganglich.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schermer, BernhardUNSPECIFIEDorcid.org/0000-0002-5194-9000UNSPECIFIED
Benzing, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-157522
DOI: 10.1055/a-0759-7180
Journal or Publication Title: Dtsch. Med. Wochenschr.
Volume: 144
Number: 4
Page Range: S. 276 - 282
Date: 2019
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-4413
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CAS; DNAMultiple languages
Medicine, General & InternalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15752

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