Universität zu Köln

Kiessling, David ORCID: 0000-0003-4341-0256, Christ, Hildegard ORCID: 0000-0003-3235-2994, Gietzelt, Caroline, Schaub, Friederike, Dietlein, Thomas S., Cursiefen, Claus, Heindl, Ludwig M. and Enders, Philip ORCID: 0000-0002-9527-4957 (2019). Impact of ab-interno trabeculectomy on Bruch's membrane opening-based morphometry of the optic nerve head for glaucoma progression analysis. Graefes Arch. Clin. Exp. Ophthalmol., 257 (2). S. 339 - 348. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

PurposeTo analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) after glaucoma surgery via ab-interno trabeculectomy in adult glaucoma patients.MethodsRetrospective audit of 65 eyes of 65 participants undergoing ab-interno trabeculectomy using electroablation of the trabecular meshwork. In 53 eyes, surgery was combined with phacoemulsification and posterior chamber lens implantation. Pre- and postoperative SD-OCT examinations of the optic nerve head (ONH), intraocular pressure (IOP), and visual field data were analyzed. Longitudinal change in morphometric SD-OCT parameters of the ONH was compared and correlated to change in IOP and visual field function.ResultsBMO-MRW increased significantly between baseline (BL) and follow-up (FU) within the first 6months after surgery (BL=167.8590m; FU=175.59 +/- 89m; p=0.034). This increase correlated with postoperative lowering of IOP (rho=-0.41; p=0.016). Nine months after surgery (range, 7-12months), there was no significant change in BMO-MRW (BL=196.79 +/- 79; FU=196.47 +/- 85m; p=0.95), while in later follow-up, a decrease of BMO-MRW was found (BL=175.18 +/- 78; FU=168.65 +/- 72; p=0.05). RNFL thickness was unchanged in early (p>0.16) and significantly decreased in later follow-up (p=0.009). Mean deviation (MD) of visual field function did not show a significant change before and after surgery.Conclusion p id= Par4 Electroablative ab-interno trabeculectomy leads to a significant transient mild increase in BMO-MRW. This increase was shown to correlate with IOP lowering. Significant loss of BMO-MRW in later follow-up may reflect insufficient IOP reduction by surgery. The parameters RNFL thickness and MD seem less impacted directly by surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kiessling, David UNSPECIFIED orcid.org/0000-0003-4341-0256 UNSPECIFIED Christ, Hildegard UNSPECIFIED orcid.org/0000-0003-3235-2994 UNSPECIFIED Gietzelt, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157820
DOI:	10.1007/s00417-018-4187-2
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	257
Number:	2
Page Range:	S. 339 - 348
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAOCULAR-PRESSURE ELEVATION; FIBER LAYER THICKNESS; MINIMUM RIM WIDTH; OPEN-ANGLE GLAUCOMA; DISC; TOMOGRAPHY; REVERSAL; TOPOGRAPHY; REDUCTION; SURGERY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15782