Enders, Philip ORCID: 0000-0002-9527-4957, Adler, Werner ORCID: 0000-0001-9791-5407, Kiessling, David ORCID: 0000-0003-4341-0256, Weber, Vincent, Schaub, Friederike, Hermann, Manuel M., Dietlein, Thomas, Cursiefen, Claus and Heindl, Ludwig M. (2019). Evaluation of two-dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort. Acta Ophthalmol., 97 (1). S. 60 - 68. HOBOKEN: WILEY. ISSN 1755-3768

Full text not available from this repository.

Abstract

Purpose To characterize the two-dimensional parameter Bruch's membrane opening minimum rim area (BMO-MRA) in spectral domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO-MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. Methods Case-control, cross-sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD-OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination. Morphometric ONH parameters, visual field function and diagnostic power were compared. Main outcome measures were SD-OCT-derived BMO-MRA, BMO-MRW, RNFL thickness and CSLT-derived rim area (DM-RA). Results Mean ONH area was 2.11 +/- 0.57 mm(2); mean BMO area was 1.89 +/- 0.45 mm(2). Correlation of mean deviation in visual field to morphometric parameters was rho = 0.70, (p < 0.001) for RNFL thickness, rho = 0.68 (p < 0.001) for BMO-MRA, rho = 0.66 (p < 0.001) for BMO-MRW. These correlations were not significantly different (p > 0.05), while DM-RA correlated significantly worse (rho = 0.55; p < 0.001). In receiver operating characteristics, the calculated area under the curve (AUC) and sensitivity at 90% specificity to differentiate glaucoma were 0.87% and 70.1% for BMO-MRA, 0.86% and 68.1% for RNFL thickness, 0.84% and 66.0% for BMO-MRW, 0.82% and 51.3% for DM-RA. Conclusions In a heterogenous clinical cohort of glaucoma patients, all analysed SD-OCT parameters excel DM-RA of CSLT. The two-dimensional parameter BMO-MRA shows comparable levels of diagnostic power to detect glaucoma compared to established parameters BMO-MRW and RNFL thickness. Given higher comparability between ONH sizes, BMO-MRA might become an additional standard tool in SD-OCT imaging for glaucoma.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Enders, PhilipUNSPECIFIEDorcid.org/0000-0002-9527-4957UNSPECIFIED
Adler, WernerUNSPECIFIEDorcid.org/0000-0001-9791-5407UNSPECIFIED
Kiessling, DavidUNSPECIFIEDorcid.org/0000-0003-4341-0256UNSPECIFIED
Weber, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaub, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermann, Manuel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietlein, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, Ludwig M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-158111
DOI: 10.1111/aos.13698
Journal or Publication Title: Acta Ophthalmol.
Volume: 97
Number: 1
Page Range: S. 60 - 68
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1755-3768
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPTICAL COHERENCE TOMOGRAPHY; NERVE-FIBER LAYER; SCANNING LASER OPHTHALMOSCOPY; SPECTRAL-DOMAIN OCT; DISC MARGIN ANATOMY; NEURORETINAL RIM; WIDTH; THICKNESS; HEADMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15811

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item