Prasetyanti, Pramudita R., van Hooff, Ander R., van Herwaarden, Tessa, de Vries, Nathalie, Kalloe, Kieshen, Rodermond, Hans, van Leersum, Ronald, de Jong, Joan H., Franitza, Marek, Nuernberg, Peter, Todaro, Matilde, Stassi, Giorgio and Medema, Jan Paul (2019). Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models. Int. J. Cancer, 144 (2). S. 366 - 372. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

Patient-derived xenograft (PDX) models have become an important asset in translational cancer research. However, to provide a robust preclinical platform, PDXs need to accommodate the tumor heterogeneity that is observed in patients. Colorectal cancer (CRC) can be stratified into four consensus molecular subtypes (CMS) with distinct biological and clinical features. Surprisingly, using a set of CRC patients, we revealed the partial representation of tumor heterogeneity in PDX models. The epithelial subtypes, the largest subgroups of CRC subtype, were very ineffective in establishing PDXs, indicating the need for further optimization to develop an effective personalized therapeutic approach to CRC. Moreover, we showed that tumor cell proliferation was associated with successful PDX establishment and able to distinguish patient with poor clinical outcomes within CMS2 group.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Prasetyanti, Pramudita R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Hooff, Ander R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Herwaarden, TessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Vries, NathalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalloe, KieshenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodermond, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leersum, RonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jong, Joan H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franitza, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todaro, MatildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stassi, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medema, Jan PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-159274
DOI: 10.1002/ijc.31767
Journal or Publication Title: Int. J. Cancer
Volume: 144
Number: 2
Page Range: S. 366 - 372
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBTYPESMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15927

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