Babatz, Felix, Naffin, Elke and Klaembt, Christian (2018). The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate Junctions. Dev. Cell, 47 (6). S. 697 - 714. CAMBRIDGE: CELL PRESS. ISSN 1878-1551

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Abstract

The blood-brain barrier is crucial for nervous system function. It is established early during development and stays intact during growth of the brain. In invertebrates, septate junctions are the occluding junctions of this barrier. Here, we used Drosophila to address how septate junctions grow during larval stages when brain size increases dramatically. We show that septate junctions are preassembled as long, highly folded strands during embryonic stages, connecting cell vertices. During subsequent cell growth, these corrugated strands are stretched out and stay intact during larval life with very little protein turnover. The G-protein coupled receptor Moody orchestrates the continuous organization of junctional strands in a process requiring F-actin. Consequently, in moody mutants, septate junction strands cannot properly stretch out during cell growth. To compensate for the loss of blood-brain barrier function, moody mutants form interdigitating cell-cell protrusions, resembling the evolutionary ancient barrier type found in primitive vertebrates or invertebrates such as cuttlefish.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Babatz, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naffin, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaembt, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-161939
DOI: 10.1016/j.devcel.2018.10.002
Journal or Publication Title: Dev. Cell
Volume: 47
Number: 6
Page Range: S. 697 - 714
Date: 2018
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1878-1551
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRICELLULAR JUNCTIONS; PROTEIN; ORGANIZATION; COMPLEX; GLIA; BINDING; SPECIALIZATION; MORPHOGENESIS; MATURATION; POLARITYMultiple languages
Cell Biology; Developmental BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16193

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