Universität zu Köln

Mueller, Roman-Ulrich and Benzing, Thomas (2018). Management of autosomal-dominant polycystic kidney disease-state-of-the-art. Clin. Kidney J., 11. S. I2 - 12. OXFORD: OXFORD UNIV PRESS. ISSN 2048-8513

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Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of end-stage renal disease in adults. Affected individuals and families face a significant medical and psychosocial burden due to both renal and extrarenal manifestations. Consequently, interventions that ameliorate the course of the disease and specifically slow down the loss of kidney function are of special interest. Major research efforts in both the clinical and pre-clinical setting in the last two decades resulted in a number of pivotal clinical trials aimed to ameliorate the disease. These studies have underlined the important role of specific supportive measures and provided the basis for first targeted pharmacological therapies. Very recently, the concept of repurposing drugs approved for other conditions for a use in ADPKD has gained increasing attention. Here, we review the current best-practice management of ADPKD patients with a focus on interventions that have reached clinical use to maintain kidney function and give an outlook on future trials and potential novel treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163042
DOI:	10.1093/ckj/sfy103
Journal or Publication Title:	Clin. Kidney J.
Volume:	11
Page Range:	S. I2 - 12
Date:	2018
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2048-8513
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIETARY-PROTEIN RESTRICTION; ANGIOTENSIN-ALDOSTERONE-SYSTEM; CONVERTING ENZYME-INHIBITION; ORTHOLOGOUS MOUSE MODEL; RENAL EPITHELIAL-CELLS; BLOOD-PRESSURE CONTROL; TIME PHYSICAL-ACTIVITY; POOLED ANALYSIS; CYST FORMATION; LIVER-DISEASE Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16304