Universität zu Köln

Braumann, Simon, Baldus, Stephan and Pfister, Roman (2018). Molecular mechanisms underlying cardiotoxicity of novel cancer therapeutics. J. Thorac. Dis., 10. S. S4335 - 9. SHATIN: AME PUBL CO. ISSN 2077-6624

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Abstract

Novel cancer therapeutics contribute to a steadily declining cancer mortality. However, several of these new therapies target pathways also involved in the cardiovascular system thus causing cardiotoxic side effects such as chemotherapy-induced heart failure (CIHF). This might limit the applicability of these effective treatments in a relevant number of patients. Furthermore, given the improving cancer survival rates, chemotherapy-induced cardiotoxic complications receive increasing attention given their potential impact on long-term morbidity and mortality. The understanding of molecular mechanisms that underlie CIHF is crucial for future improvement of pharmacodynamics of these therapeutics but also for developing specific interventions to prevent CIHF. Here, we discuss molecular mechanisms underlying CIHF of novel cancer therapeutics including a short synopsis on clinical management of patients suffering from CIHF.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Braumann, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163116
DOI:	10.21037/jtd.2018.10.107
Journal or Publication Title:	J. Thorac. Dis.
Volume:	10
Page Range:	S. S4335 - 9
Date:	2018
Publisher:	AME PUBL CO
Place of Publication:	SHATIN
ISSN:	2077-6624
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VASCULAR-PERMEABILITY FACTOR; METASTATIC BREAST-CANCER; PLURIPOTENT STEM-CELLS; CARDIAC DYSFUNCTION; INHIBITOR SUNITINIB; DOUBLE-BLIND; CARDIOVASCULAR TOXICITY; PROTEASOME INHIBITION; PHASE-II; HYPERTENSION Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16311