Universität zu Köln

Rinschen, Markus M., Huesgen, Pitter F. and Koch, Rachelle E. (2018). The podocyte protease web: uncovering the gatekeepers of glomerular disease. Am. J. Physiol.-Renal Physiol., 315 (6). S. F1812 - 5. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1466

Full text not available from this repository.

Abstract

Proteases regulate glomerular physiology. The last decade has revealed a multitude of podocyte proteases that govern the glomerular response to numerous chemical, mechanical, and metabolic cues. These proteases form a protein signaling web that integrates stress stimuli and serves as a key controller of the glomerular microenvironment. Both the extracellular and intracellular proteolytic networks are perturbed in focal segmental glomerulosclerosis, as well as hypertensive and diabetic nephropathy. Accordingly, the highly intertwined podocyte protease web is an integrative part of the podocyte's damage response. Novel mass spectrometry-based technologies will help to untangle this proteolytic network: functional readouts acquired from deep podocyte proteomics, single glomerular proteomics, and degradomics have exposed unanticipated protease activity in podocytes. Future efforts should characterize the interdependency and upstream regulation of key proteases, along with their role in promoting tissue heterogeneity in glomerular diseases. These efforts will not only illuminate the machinery of podocyte proteostasis but also reveal avenues for therapeutic intervention in the podocyte protease web.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rinschen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huesgen, Pitter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Rachelle E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163161
DOI:	10.1152/ajprenal.00380.2018
Journal or Publication Title:	Am. J. Physiol.-Renal Physiol.
Volume:	315
Number:	6
Page Range:	S. F1812 - 5
Date:	2018
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1466
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CATHEPSIN-L; KIDNEY-DISEASE; DIABETIC-NEPHROPATHY; ENDOTHELIAL-CELLS; NOTCH PATHWAY; EXPRESSION; PROTEINURIA; THROMBIN; NETWORK; INJURY Multiple languages Physiology; Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16316