Universität zu Köln

Olbrich, Kerstin J., Mueller, Dirk, Schumacher, Sarah, Beck, Ekkehard, Meszaros, Kinga and Koerber, Florian (2018). Systematic Review of Invasive Meningococcal Disease: Sequelae and Quality of Life Impact on Patients and Their Caregivers. Infect. Dis. Ther., 7 (4). S. 421 - 439. LONDON: SPRINGER LONDON LTD. ISSN 2193-6382

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Abstract

Introduction: Invasive meningococcal disease (IMD, septicaemia and/or meningitis) has a severe acute and long-term burden: 5-10% of patients die within 48h, and long-term sequelae have been reported in 10-20% of survivors. Health-related quality of life (HRQoL) is increasingly but inconsistently assessed. Methods: A systematic literature review on Neisseria meningitidis IMD sequelae and HRQoL in survivors of all ages and their caregivers, including family, was conducted for high-income countries from 2001 to 2016 (in Medline and Embase, following Cochrane and PRISMA guidelines). Results: A total of 31 studies, mostly of childhood IMD cases, were included. A broad range of physical, neurological and psychological IMD sequelae were identified. The literature has evolved, with more types of sequelae reported in more recent studies; however, meningococcal disease-specific and sequelae-specific HRQoL data are lacking, and existing studies used a wide variety of instruments. Physical sequelae included: amputations (up to 8% of children, 3% adolescents/adults) and skin scars (up to 55% of children, 18% adolescents, 2% adults). Neurologic sequelae included: hearing loss (up to 19% of infants, 13% children, 12% adolescents, 8% adults). Psychological sequelae included: anxiety, learning difficulties, emotional and behavioural difficulties. IMD negatively affects HRQoL in patients and also in their family and close caregiver network, both in the short- and long-term. Even IMD survivors without sequelae experienced an adverse impact on HRQoL after many years, affecting self-esteem, physical, mental and psychosocial health, and HRQoL was worse in those with cognitive and behavioural sequelae. Conclusion: A high proportion of IMD survivors are affected by a broad range of sequelae and reduced HRQoL that persists years after infection. Childhood IMD survivors had more sequelae and more severe sequelae compared with adult survivors. HRQoL was affected in patients and also in their families, caregivers and surrounding network over the long term. More research is needed to resolve data gaps and to standardise HRQoL assessment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Olbrich, Kerstin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Beck, Ekkehard UNSPECIFIED UNSPECIFIED UNSPECIFIED Meszaros, Kinga UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerber, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164590
DOI:	10.1007/s40121-018-0213-2
Journal or Publication Title:	Infect. Dis. Ther.
Volume:	7
Number:	4
Page Range:	S. 421 - 439
Date:	2018
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	2193-6382
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERM-FOLLOW-UP; SEPTIC SHOCK; NEISSERIA-MENINGITIDIS; BACTERIAL-MENINGITIS; CLINICAL-FEATURES; CHILDREN; SURVIVORS; OUTCOMES; ADOLESCENTS; CHILDHOOD Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16459