Universität zu Köln

Mellinghoff, Sibylle C., Cornely, O. A. and Jung, N. (2018). Essentials in Candida bloodstream infection. Infection, 46 (6). S. 897 - 900. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Aims Due to the increase of severely immunocompromised patients, of invasive procedures including central intravascular catheters, and of the use of broad-spectrum antibiotics, the incidence of Candida bloodstream infections has risen intensely in the last decades. Candida bloodstream infection is a serious disease with high mortality. Optimized diagnostic and therapeutic management can improve outcome. Thus, the aim of our mini-review is to highlight important and often missed opportunities in the management of Candida bloodstream infection. Methods We searched the published literature and describe the essentials in the management of Candida bloodstream infection. Results Four essentials were identified: (1) isolation of Candida spp. from a blood culture should always be considered relevant and requires treatment. Daily blood cultures should be drawn to determine cessation of candidemia. (2) Central venous catheter (CVC) and/or other indwelling devices should be removed. (3) Echinocandins are the first choice. Antifungal treatment should be continued for at least 14 days after cessation of fungemia. Susceptibility testing should be performed to identify resistance and to facilitate transition to oral treatment. (4) In persistent candidemia, echocardiography is an important investigation; ophthalmoscopy should be considered. Conclusion Further efforts should be undertaken to increase the adherence to the essentials in the management of Candia bloodstream infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164634
DOI:	10.1007/s15010-018-1218-1
Journal or Publication Title:	Infection
Volume:	46
Number:	6
Page Range:	S. 897 - 900
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMPHOTERICIN-B; DISEASES SOCIETY; CASPOFUNGIN; MANAGEMENT; FLUCONAZOLE; MICAFUNGIN; GUIDELINE; OUTCOMES; UPDATE; TRIAL Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16463