Bewernick, Bettina H., Kilian, Hannah M., Schmidt, Klaudius, Reinfeldt, Ruth E., Kayser, Sarah, Coenen, Volker A., Markett, Sebastian and Schlaepfer, Thomas E. (2018). Deep brain stimulation of the supero-lateral branch of the medial forebrain bundle does not lead to changes in personality in patients suffering from severe depression. Psychol. Med., 48 (16). S. 2684 - 2693. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-8978

Full text not available from this repository.

Abstract

Background. Reports of changes in patients' social behavior during deep brain stimulation (DBS) raised the question whether DBS induces changes in personality. This study explored if (1) DBS is associated with changes in personality in patients suffering from treatment-resistant depression (TRD), (2) how personality dimensions and depression are associated, and (3) if TRD patients' self-ratings of personality are valid. Methods. TRD patients were assessed before DBS (n = 30), 6 months (t2, n = 21), 2 (t3, n = 17) and 5 years (t4, n = 11) after the initiation of DBS of the supero-lateral branch of the medial forebrain bundle (slMFB-DBS). Personality was measured with the NEO-Five-Factor Inventory (NEO-FFI), depression severity with Hamilton (HDRS), and Montgomery-angstrom sberg Depression Rating Scale (MADRS). Results. Personality dimensions did not change with slMFB-DBS compared with baseline. Extraversion was negatively correlated with HDRS28 (r = -0.48, p < 0.05) and MADRS (r = -0.45, p < 0.05) at t2. Inter-rater reliability was high for the NEO-FFI at baseline (Cronbach's = 0.74) and at t4 ( alpha= 0.65). Extraversion [t((29)) = -5.20; p < 0.001] and openness to experience [t((29)) = -6.96; p < 0.001] differed statistically significant from the normative sample, and did not predict the antidepressant response. Conclusions. slMFB-DBS was not associated with a change in personality. The severity of depression was associated with extraversion. Personality of TRD patients differed from the healthy population and did not change with response, indicating a possible scar effect. Self-ratings of personality seem valid to assess personality during TRD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bewernick, Bettina H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilian, Hannah M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, KlaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinfeldt, Ruth E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kayser, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coenen, Volker A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markett, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaepfer, Thomas E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-164698
DOI: 10.1017/S0033291718000296
Journal or Publication Title: Psychol. Med.
Volume: 48
Number: 16
Page Range: S. 2684 - 2693
Date: 2018
Publisher: CAMBRIDGE UNIV PRESS
Place of Publication: NEW YORK
ISSN: 1469-8978
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TREATMENT-RESISTANT DEPRESSION; SELF-REPORT; MAJOR DEPRESSION; TERM OUTCOMES; ANXIETY; TRAITS; DISORDERS; RATINGS; SCALEMultiple languages
Psychology, Clinical; Psychiatry; PsychologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16469

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item