Tomic-Canic, Majana, Wong, Lulu L. and Smola, Hans (2018). The epithelialisation phase in wound healing: options to enhance wound closure. J. Wound Care, 27 (10). S. 646 - 658. LONDON: MA HEALTHCARE LTD. ISSN 2062-2916

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Abstract

This review highlights epithelialisation and therapeutic options to optimise and speed the epithelialisation process. To influence this process therapeutically, it is important for clinicians to understand the underlying principles of epithelialisation. The role of growth factors and the hostile local wound environment can explain why epithelial wound closure is so difficult to speed up in some chronic wounds. Clinicians should be aware of the different surgical techniques of skin grafting and more advanced technologies, such as skin substitutes, as options for wounds which fail to respond to standard protocols. Finally, novel dressing-based concepts are discussed, including macromolecular crowding, a concept which aims at boosting growth factor activities produced in the wound space once wound healing is normalised and underway. Declaration of interest: HS is a full-time employee of PAUL HARTMANN, a medical device manufacturer. MT-C has no conflict of interest to declare relating to this paper.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tomic-Canic, MajanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, Lulu L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smola, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-170392
DOI: 10.12968/jowc.2018.27.10.646
Journal or Publication Title: J. Wound Care
Volume: 27
Number: 10
Page Range: S. 646 - 658
Date: 2018
Publisher: MA HEALTHCARE LTD
Place of Publication: LONDON
ISSN: 2062-2916
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; ADULT HUMAN KERATINOCYTES; COLONY-STIMULATING FACTOR; SKIN CELL-MIGRATION; FACTOR-ALPHA; MITOGENIC ACTIVITY; LEG ULCERS; TGF-ALPHA; TEMPORAL EXPRESSIONMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17039

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