Ruedrich, Urda, Gehring, Manuela, Papakonstantinou, Eleni, Illerhaus, Anja, Engmann, Judith, Kapp, Alexander ORCID: 0000-0002-1748-6276, Hartmann, Karin ORCID: 0000-0002-4595-8226, Meyer, N. Helge, Gibbs, Bernhard F. and Raap, Ulrike (2018). Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid. Acta Derm.-Venereol., 98 (8). S. 766 - 772. UPPSALA: ACTA DERMATO-VENEREOLOGICA. ISSN 1651-2057

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Abstract

Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine whether IL-31 plays a role in BP. Using immunofluorescence, IL-31 expression was analysed in eosinophils derived from blister fluids and skin from patients with BP and IL-31 levels in blister fluids, serum and culture supernatants were determined by enzyme-linked immunoassay (ELISA). High levels of IL-31 expression were observed in BP blister fluids, but they were only marginally elevated in BP serum compared with healthy controls. Eosinophils from either BP blister fluids or skin biopsies showed strong expression of IL-31. Furthermore, peripheral blood eosinophils from patients with BP, but not healthy controls, released high levels of IL-31, reflecting those in blister fluids. In conclusion, eosinophils are a major source of IL-31 in BP and this cytokine may contribute to itch in patients with BP.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ruedrich, UrdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gehring, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papakonstantinou, EleniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illerhaus, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engmann, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kapp, AlexanderUNSPECIFIEDorcid.org/0000-0002-1748-6276UNSPECIFIED
Hartmann, KarinUNSPECIFIEDorcid.org/0000-0002-4595-8226UNSPECIFIED
Meyer, N. HelgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibbs, Bernhard F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raap, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-175077
DOI: 10.2340/00015555-2951
Journal or Publication Title: Acta Derm.-Venereol.
Volume: 98
Number: 8
Page Range: S. 766 - 772
Date: 2018
Publisher: ACTA DERMATO-VENEREOLOGICA
Place of Publication: UPPSALA
ISSN: 1651-2057
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IL-31 SERUM-LEVELS; T-CELLS; ATOPIC-DERMATITIS; DISEASE-ACTIVITY; CORRELATE; RECEPTOR; EXPRESSION; PRURITUS; SKIN; SEVERITYMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17507

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