Universität zu Köln

Schulz, Jan-Nikias, Plomann, Markus, Sengle, Gerhard, Gullberg, Donald ORCID: 0000-0002-7245-4437, Krieg, Thomas and Eckes, Beate (2018). New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts. Matrix Biol., 68-69. S. 522 - 533. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1569-1802

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Abstract

Many different diseases are associated with fibrosis of the skin. The clinical symptoms can vary considerably with a broad range from isolated small areas to the involvement of the entire integument. Fibrosis is triggered by a multitude of different stimuli leading to activation of the immune and vascular system that then initiate fibroblast activation and formation of matrix depositing and remodeling myofibroblasts. Ultimately, myofibroblasts deposit excessive amounts of extracellular matrix with a pathological architecture and alterations in growth factor binding and biomechanical properties, which culminates in skin hardening and loss of mobility. Treatment depends certainly on the specific type and cause of the disease, for the autoimmune driven localized and systemic scleroderma therapeutic options are still limited, but recent research has pointed out diverse molecular targets and mechanisms that can be exploited for the development of novel antifibrotic therapy. (C) 2018 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schulz, Jan-Nikias UNSPECIFIED UNSPECIFIED UNSPECIFIED Plomann, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gullberg, Donald UNSPECIFIED orcid.org/0000-0002-7245-4437 UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177386
DOI:	10.1016/j.matbio.2018.01.025
Journal or Publication Title:	Matrix Biol.
Volume:	68-69
Page Range:	S. 522 - 533
Date:	2018
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1569-1802
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-BETA; INTEGRIN-LINKED KINASE; SYSTEMIC-SCLEROSIS; TISSUE-REPAIR; TGF-BETA; ALPHA-11-BETA-1 INTEGRIN; SCLERODERMA SKIN; INCREASED EXPRESSION; COLLAGEN SECRETION; GRANULATION-TISSUE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17738