Universität zu Köln

Jakobsen, J. R., Jakobsen, N. R., Mackey, A. L., Koch, M., Kjaer, M. and Krogsgaard, M. R. (2018). Remodeling of muscle fibers approaching the human myotendinous junction. Scand. J. Med. Sci. Sports, 28 (8). S. 1859 - 1866. HOBOKEN: WILEY. ISSN 1600-0838

Full text not available from this repository.

Abstract

The myotendinous junction (MTJ) is at high risk of strain injuries, due to high amounts of energy that is transferred through this structure. The risk of strain injury is significantly reduced by heavy resistance training (HRT), indicating a remodeling capacity of MTJ. We investigated the degree of remodeling of muscle fibers near the human MTJ. In 8 individuals, samples were taken from the semitendinosus and gracilis MTJ and they were stained immunohistochemically for myonuclei (DAPI), fibroblasts (TCF7L2), and satellite cells (CD56). A high portion of the muscle fibers adjacent to the MTJ contained a centrally located myonucleus (47 +/- 8%, mean +/- SD) and half of the muscle fibers were CD56 positive. The number of satellite cells and fibroblasts were not higher than what has previously been reported from muscle bellies. The immunohistochemical findings suggest that the rate of remodeling of muscle fibers near the MTJ is very high. The finding that there was no increased number of satellite cells and fibroblasts could be explained as a dynamic phenomenon. The effect of HRT should be evaluated in a randomized setting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jakobsen, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobsen, N. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mackey, A. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kjaer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krogsgaard, M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177547
DOI:	10.1111/sms.13196
Journal or Publication Title:	Scand. J. Med. Sci. Sports
Volume:	28
Number:	8
Page Range:	S. 1859 - 1866
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONNECTIVE-TISSUE FIBROBLASTS; SKELETAL-MUSCLE; SATELLITE CELLS; HAMSTRING INJURIES; ANABOLIC-STEROIDS; STRAIN INJURY; OLDER MEN; IN-VIVO; REGENERATION; EXERCISE Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17754