Universität zu Köln

Buxhofer-Ausch, Veronika, Steurer, Michael, Sormann, Siegfried, Schloegl, Ernst, Schimetta, Wolfgang, Gisslinger, Bettina, Schalling, Martin, Krauth, Maria Theresa, Thiele, Juergen, Ruckser, Reinhard, Gastl, Guenther and Gisslinger, Heinz (2018). Impact of white blood cells on thrombotic risk in patients with optimized platelet count in essential thrombocythemia. Eur. J. Haematol., 101 (2). S. 131 - 136. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

ObjectivesRisk of thrombosis is significantly enhanced by both elevated platelet (PLT) and white blood cell (WBC) counts according to a retrospective analysis of a large anagrelide registry in thrombocythemic MPN patients. We were interested in the impact of elevated WBC counts on thrombosis risk in patients where PLT counts were reduced below the calculated cutoff of 574.5G/L by treatment with anagrelide. MethodsCox regression analysis and Kaplan-Meier plot were applied on all patients in the registry with optimized PLT counts. ResultsUsing the calculated cutoff of 9.66G/L for WBC, Cox regression analysis revealed a clear influence of elevated WBC counts on the occurrence of a major thrombotic event (P=.012). A Kaplan-Meier plot revealed a markedly shorter time to a major thrombotic event for patients with WBC counts above the cutoff (P=.001). ConclusionsThese data suggest that additional correction of elevated WBC counts is mandatory in patients with optimally managed PLT counts to reduce thrombotic risk. This study is the first investigation in a prospectively observed large patient cohort which was treated homogenously allowing for evaluation of single parameters for an effect on thrombophilia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buxhofer-Ausch, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Steurer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sormann, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Schloegl, Ernst UNSPECIFIED UNSPECIFIED UNSPECIFIED Schimetta, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schalling, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauth, Maria Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruckser, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gastl, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-178839
DOI:	10.1111/ejh.13070
Journal or Publication Title:	Eur. J. Haematol.
Volume:	101
Number:	2
Page Range:	S. 131 - 136
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VASCULAR COMPLICATIONS; HYDROXYUREA; ANAGRELIDE; MYELOFIBROSIS; LEUKOCYTOSIS; DIAGNOSIS; ARTERIAL; REGISTRY Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17883