Bohn, Barbara ORCID: 0000-0001-8363-943X, Moenkemoeller, Kirsten, Hilgard, Doerte, Dost, Axel, Schwab, Karl Otfried, Lilienthal, Eggert, Hammer, Elke, Hake, Kathrin, Fritsch, Maria, Gohlke, Bettina, de Beaufort, Carine and Holl, Reinhard W. (2018). Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg. Pediatr. Diabetes, 19 (5). S. 937 - 945. HOBOKEN: WILEY. ISSN 1399-5448

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Abstract

Objective: To investigate differences in cardiovascular risk factors and metabolic control in girls with type 1 diabetes with or without use of oral contraceptives (OC) from the multicenter diabetes prospective follow-up (DPV) registry. Methods: Twenty-four thousand eleven adolescent girls (13 to < 18 years of age) from Germany, Austria or Luxembourg with type 1 diabetes from the DPV registry were included in this cross-sectional study. Multivariable regression models were applied to compare clinical characteristics (hemoglobin A1c [HbA1(C)], blood pressure, serum lipids, body mass index) and lifestyle factors (smoking, physical inactivity, alcohol consumption) between girls with or without OC use. Confounders: age, diabetes duration and migration background. Statistical analysis: SAS 9.4. Results: In girls with type 1 diabetes and OC use, clinical characteristics and lifestyle factors were less favorable compared to non-users. Differences were most pronounced for the prevalence of dyslipidemia (OC-users: 40.0% vs non-users: 29.4; P <.0001) and the number of smokers (OC-users: 25.9% vs non-users: 12.5%; P <.0001). OC use, sociodemographic characteristics and lifestyle factors explained between 1 and 7% of the population variance in serum lipids and blood pressure. The use of OC explained a small additional proportion in all variables considered (<1%). Conclusions: OC use in adolescent girls with type 1 diabetes was associated with a poorer cardiovascular risk profile. Biological risk factors were partly explained by a clustering of sociodemographic and lifestyle factors with a small additional contribution of OC use. Prescription of OC should therefore be combined with a screening for cardiovascular risk factors and targeted education.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bohn, BarbaraUNSPECIFIEDorcid.org/0000-0001-8363-943XUNSPECIFIED
Moenkemoeller, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilgard, DoerteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dost, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwab, Karl OtfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lilienthal, EggertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammer, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hake, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fritsch, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gohlke, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Beaufort, CarineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holl, Reinhard W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-179244
DOI: 10.1111/pedi.12656
Journal or Publication Title: Pediatr. Diabetes
Volume: 19
Number: 5
Page Range: S. 937 - 945
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1399-5448
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
METABOLIC-CONTROL; WOMEN; CHILDREN; PREGNANCY; MELLITUS; SMOKING; MANAGEMENT; BEHAVIORS; EXPOSURES; TRACKINGMultiple languages
Endocrinology & Metabolism; PediatricsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17924

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