Universität zu Köln

Schlabe, Stefan, van Bremen, Kathrin, Aldabbagh, Souhaib, Glebe, Dieter, Bremer, Corinna M., Marsen, Tobias, Mellin, Walter, Di Cristanziano, Veronica, Eis-Hubinger, Anna M. and Spengler, Ulrich (2018). Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature. World J. Hepatol., 10 (7). S. 509 - 517. PLEASANTON: BAISHIDENG PUBLISHING GROUP INC. ISSN 1948-5182

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Abstract

Hepatitis B represents a global health threat because its chronic course and sequelae contribute to a high morbidity and mortality. Hepatitis B virus (HBV) infection can be controlled by vaccines, antiviral treatment, and by interrupting transmission. Rare vaccine escape mutants are serious because they eliminate vaccine protection. Here, we present a 74-year-old vaccinated patient with HBV reactivation 11 years after kidney transplantation. The patient was HBV-positive but HBsAg-negative prior to vaccination 6 years before transplantation. The reactivated virus was HBV genotype F3 with vaccine escape mutations G145R, P120Q, and Q129P. The patient was successfully treated with entecavir. The epidemiological reasons for this sub-genotype, which is extremely rare in Western Europe, were unclear. This case illustrates that second-generation vaccines are not always effective in a specific group of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlabe, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED van Bremen, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Aldabbagh, Souhaib UNSPECIFIED UNSPECIFIED UNSPECIFIED Glebe, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bremer, Corinna M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marsen, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Mellin, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Eis-Hubinger, Anna M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spengler, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179437
DOI:	10.4254/wjh.v10.i7.509
Journal or Publication Title:	World J. Hepatol.
Volume:	10
Number:	7
Page Range:	S. 509 - 517
Date:	2018
Publisher:	BAISHIDENG PUBLISHING GROUP INC
Place of Publication:	PLEASANTON
ISSN:	1948-5182
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SURFACE-ANTIGEN; INFECTION; GENOTYPES; EFFICACY; VARIANT Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17943