Meister, Anne, Hentrich, Marcus, Wyen, Christoph and Huebel, Kai (2018). Malignant lymphoma in the HIV-positive patient. Eur. J. Haematol., 101 (1). S. 119 - 127. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

The introduction of combination antiretroviral therapy (cART) drastically improved performance status, immune function, and life expectancy of HIV-infected individuals. In addition, incidence of opportunistic infections and of AIDS-defining malignancies declined. Nevertheless, aggressive non-Hodgkin's lymphoma still remains the leading cause of AIDS-related deaths. The availability of cART, however, significantly improved the therapeutic options for HIV-positive patients with lymphomas. Diffuse large B-cell lymphoma, Burkitt's lymphoma, or Hodgkin lymphoma has increasingly become curable diseases. In light of these favorable developments in the treatment of HIV and HIV-associated lymphomas, reduction in treatment-associated toxicities and further improvement of outcome of patients with advanced immune suppression are major requirements for future clinical trials. This review summarizes the current treatment landscape and gives an overview on future needs in HIV-positive patients with lymphoma.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Meister, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hentrich, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebel, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-180290
DOI: 10.1111/ejh.13082
Journal or Publication Title: Eur. J. Haematol.
Volume: 101
Number: 1
Page Range: S. 119 - 127
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-0609
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HUMAN-IMMUNODEFICIENCY-VIRUS; B-CELL LYMPHOMA; NON-HODGKIN-LYMPHOMA; ACTIVE ANTIRETROVIRAL THERAPY; PRIMARY EFFUSION LYMPHOMA; MULTICENTRIC CASTLEMANS-DISEASE; NERVOUS-SYSTEM LYMPHOMA; AIDS-RELATED LYMPHOMA; MABTHERA INTERNATIONAL TRIAL; ITALIAN COOPERATIVE GROUPMultiple languages
HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18029

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