Walker, Zuzana ORCID: 0000-0001-7346-8200, Gandolfo, Federica, Orini, Stefania, Garibotto, Valentina ORCID: 0000-0003-2422-698X, Agosta, Federica ORCID: 0000-0003-3121-4979, Arbizu, Javier ORCID: 0000-0002-8370-5510, Bouwman, Femke, Drzezga, Alexander, Nestor, Peter ORCID: 0000-0002-5860-5921, Boccardi, Marina ORCID: 0000-0001-6744-8246, Altomare, Daniele ORCID: 0000-0003-1905-8993, Festari, Cristina ORCID: 0000-0003-3597-5097 and Nobili, Flavio ORCID: 0000-0001-9811-0897 (2018). Clinical utility of FDG PET in Parkinson's disease and atypical parkinsonism associated with dementia. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1534 - 1546. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

There are no comprehensive guidelines for the use of FDG PET in the following three clinical scenarios: (1) diagnostic work-up of patients with idiopathic Parkinson's disease (PD) at risk of future cognitive decline, (2) discriminating idiopathic PD from progressive supranuclear palsy, and (3) identifying the underlying neuropathology in corticobasal syndrome. We therefore performed three literature searches and evaluated the selected studies for quality of design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were the sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG PET in detecting the target condition. Using the Delphi method, a panel of seven experts voted for or against the use of FDG PET based on published evidence and expert opinion. Of 91 studies selected from the three literature searches, only four included an adequate quantitative assessment of the performance of FDG PET. The majority of studies lacked robust methodology due to lack of critical outcomes, inadequate gold standard and no head-to-head comparison with an appropriate reference standard. The panel recommended the use of FDG PET for all three clinical scenarios based on nonquantitative evidence of clinical utility. Despite widespread use of FDG PET in clinical practice and extensive research, there is still very limited good quality evidence for the use of FDG PET. However, in the opinion of the majority of the panellists, FDG PET is a clinically useful imaging biomarker for idiopathic PD and atypical parkinsonism associated with dementia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Walker, ZuzanaUNSPECIFIEDorcid.org/0000-0001-7346-8200UNSPECIFIED
Gandolfo, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orini, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garibotto, ValentinaUNSPECIFIEDorcid.org/0000-0003-2422-698XUNSPECIFIED
Agosta, FedericaUNSPECIFIEDorcid.org/0000-0003-3121-4979UNSPECIFIED
Arbizu, JavierUNSPECIFIEDorcid.org/0000-0002-8370-5510UNSPECIFIED
Bouwman, FemkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nestor, PeterUNSPECIFIEDorcid.org/0000-0002-5860-5921UNSPECIFIED
Boccardi, MarinaUNSPECIFIEDorcid.org/0000-0001-6744-8246UNSPECIFIED
Altomare, DanieleUNSPECIFIEDorcid.org/0000-0003-1905-8993UNSPECIFIED
Festari, CristinaUNSPECIFIEDorcid.org/0000-0003-3597-5097UNSPECIFIED
Nobili, FlavioUNSPECIFIEDorcid.org/0000-0001-9811-0897UNSPECIFIED
URN: urn:nbn:de:hbz:38-180357
DOI: 10.1007/s00259-018-4031-2
Journal or Publication Title: Eur. J. Nucl. Med. Mol. Imaging
Volume: 45
Number: 9
Page Range: S. 1534 - 1546
Date: 2018
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1619-7089
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL GLUCOSE-METABOLISM; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL-DIAGNOSIS; F-18-FDG PET; CORTICOBASAL SYNDROME; COGNITIVE IMPAIRMENT; BRAIN NETWORKS; PATTERNS; PSPMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18035

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