Gebauer, F., Damanakis, A. I. and Bruns, C. (2018). Oligometastasis in pancreatic cancer. Current state of knowledge and spectrum of local therapy. Chirurg, 89 (7). S. 510 - 516. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0385

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Abstract

Several case series reported results of surgical resection in patients with pancreatic ductal adenocarcinoma in a metastasized stage. A summarized overview of the current state of knowledge and a summary of the results of currently available studies. A systematic search was carried out in MEDLINE and PubMed with respect to metastasized pancreatic cancer and surgical resection. The evidence level for surgical resection in the metastasized stage is weak and so far no prospective trials are available. The largest single-arm trial included 85 patients with hepatic metastasis. In cases of hepatic oligometastasis an overall survival of 11-14 months was observed. In the presence of pulmonary metastasis, overall survival seems to be prolonged compared to intra-abdominal metastasis, although the evidence level is relatively weak. According to the available results, a general recommendation for surgical resection in a metastasized stage cannot be given; however, the results show a possible benefit for some well-selected patient subgroups. Prospective trials must validate these data and investigate the use of combined surgical and systemic treatments in the case of resectable metastatic pancreatic cancer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gebauer, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damanakis, A. I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-181776
DOI: 10.1007/s00104-018-0626-1
Journal or Publication Title: Chirurg
Volume: 89
Number: 7
Page Range: S. 510 - 516
Date: 2018
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1433-0385
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DUCTAL ADENOCARCINOMA; LIVER METASTASIS; CURATIVE INTENT; RESECTION; SURVIVAL; SURGERY; GEMCITABINE; MANAGEMENT; PROGNOSIS; PATTERNSMultiple languages
SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18177

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