Universität zu Köln

da Silva, N. A., Lohmann, P., Fairney, J., Magill, A. W., Peusquens, A. -M. Oros, Choi, C. -H., Stirnberg, R., Stoffels, G., Galldiks, N., Golay, X., Langen, K. -J. and Shah, N. Jon ORCID: 0000-0002-8151-6169 (2018). Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. Eur. J. Nucl. Med. Mol. Imaging, 45 (6). S. 1031 - 1041. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose PET using radiolabelled amino acids has become a promising tool in the diagnostics of gliomas and brain metastasis. Current research is focused on the evaluation of amide proton transfer (APT) chemical exchange saturation transfer (CEST) MR imaging for brain tumour imaging. In this hybridMR-PETstudy, brain tumours were compared using 3D data derived from APT-CEST MRI and amino acid PET using O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET). Methods Eight patients with gliomas were investigated simultaneously with F-18-FET PET and APT-CEST MRI using a 3-T MR-BrainPETscanner. CEST imaging was based on a steady-state approach using a B-1 average power of 1 mu T. B-0 field inhomogeneities were corrected a Prametric images of magnetisation transfer ratio asymmetry (MTRasym) and differences to the extrapolated semisolid magnetisation transfer reference method, APT# and nuclear Overhauser effect (NOE#), were calculated. Statistical analysis of the tumour-to-brain ratio of the CEST data was performed against PET data using the non-parametric Wilcoxon test. Results A tumour-to-brain ratio derived from APT# and F-18-FET presented no significant differences, and no correlation was found between APT# and F-18-FET PET data. The distance between local hot spot APT# and F-18-FETwere different (average 20 +/- 13 mm, range 4-45 mm). Conclusion For the first time, CEST images were compared with F-18-FET in a simultaneous MR-PET measurement. Imaging findings derived from F-18-FET PETand APT CESTMRI seem to provide different biological information. The validation of these imaging findings by histological confirmation is necessary, ideally using stereotactic biopsy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code da Silva, N. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fairney, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Magill, A. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peusquens, A. -M. Oros UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, C. -H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stirnberg, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Golay, X. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, K. -J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-183302
DOI:	10.1007/s00259-018-3940-4
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	6
Page Range:	S. 1031 - 1041
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTON-TRANSFER APT; HIGH-GRADE GLIOMAS; TRANSFER CEST MRI; IN-VIVO; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; MAGNETIZATION-TRANSFER; RESPONSE ASSESSMENT; CEREBRAL GLIOMAS; GLUCOSE-UPTAKE; 7 T Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18330