Universität zu Köln

Ihle, Peter, Dippel, Franz-Werner and Schubert, Ingrid (2018). Statin-associated myopathy. Assessment of frequency based on data of all statutory health insurance funds in Germany. Pharmacol. Res. Perspect., 6 (3). CHICHESTER: JOHN WILEY & SONS LTD. ISSN 2052-1707

Full text not available from this repository.

Abstract

Aim of the study was to assess the incidence of statin-associated myopathy (SAM) under real-life conditions in Germany. Database: Administrative data (master data, diagnoses, prescriptions) for all individuals in Germany insured with the Statutory Health Insurance. Basic population: individuals 18years and older who have been insured continually from 2009 to 2011 (52.9million; 29.9million men, 23.9million women). Data access is provided by the German Institute of Medical Documentation and Information, DIMDI) according to the Data Transparency Regulation of 2012. Statins: identification with the ATC-Codes: C10AA, C10BA and C10BX. Study population: incident statin users in 2010 with a diagnosis of lipid disorders (ICD-10-GM E78, excluding patients with: E78.1, E78.3, E78.6 in eight quarters before index prescription. Definition of SAM: documentation of myopathy (ICD-10-GM G72.0, G72.8; G72.9, M60.8, M60.9, M79.1) in the first statin prescription quarter or in one of the three following quarters. The first event is considered for the incidence estimate. The daily doses included in a package were classified as days under therapy (by assuming one DDD) and taken as exposition time. SAM was found in 1.9% of 531672 incident statin users. The percentage differs according to the patterns of statin use: the lowest incidence is observed in those with only one prescription (1.3%), the highest incidence with 5.0% is observed in those who not only stopped the treatment within 365days, but who also had their statin changed. Administrative data including diagnoses from ambulatory care provide a realistic estimate of SAM frequency in every day practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ihle, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Dippel, Franz-Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-184909
DOI:	10.1002/prp2.404
Journal or Publication Title:	Pharmacol. Res. Perspect.
Volume:	6
Number:	3
Date:	2018
Publisher:	JOHN WILEY & SONS LTD
Place of Publication:	CHICHESTER
ISSN:	2052-1707
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPID-LOWERING DRUGS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; INTOLERANCE; PREVENTION; CARE; DISCONTINUATION; NONADHERENCE; CHOLESTEROL; PREVALENCE Multiple languages Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18490