Zelniker, Thomas A., Huscher, Doerte, Vonk-Noordegraaf, Anton, Ewert, Ralf, Lange, Tobias J., Klose, Hans, Dumitrescu, Daniel, Halank, Michael, Held, Matthis, Gall, Henning, Pittrow, David, Hoeper, Marius M. and Frankenstein, Lutz (2018). The 6MWT as a prognostic tool in pulmonary arterial hypertension: results from the COMPERA registry. Clin. Res. Cardiol., 107 (6). S. 460 - 471. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

Full text not available from this repository.

Abstract

Background In patients with pulmonary arterial hypertension, the 6-Minute Walk Test (6MWT) is recommended for risk stratification and follow-up by all guidelines. However, the prognostic value of the 6MWT has been discussed controversially. We sought to compare and validate all published 6MWT cut-off points. Methods From the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)-registry we identified 2391 patients with pulmonary arterial hypertension who had at least one documented 6MWT measurement. A Medline search identified a total of 21 different threshold values for either single-point or change of 6MWT. All values were tested individually for prognostication of 1-year, 2-year and 3-year all-cause mortality. Results The highest positive likelihood ratio was a cut-off value < 165 ms, whereas the best negative likelihood ratio was found to be a threshold of 440 ms. Furthermore, improvement in 6MWT had considerably less predictive value on mortality and survival than deterioration. Moreover, absolute single-point values outperformed change values for both improvement and worsening. Conclusion Our data confirmed the prognostic relevance of the 6MWT and support the cut-off values stated in most recent guidelines. Furthermore, these results explain why changes in 6MWT did not correlate consistently with prognosis in previous studies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zelniker, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huscher, DoerteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vonk-Noordegraaf, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewert, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, Tobias J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klose, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumitrescu, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halank, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Held, MatthisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gall, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pittrow, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeper, Marius M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frankenstein, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-185631
DOI: 10.1007/s00392-018-1207-5
Journal or Publication Title: Clin. Res. Cardiol.
Volume: 107
Number: 6
Page Range: S. 460 - 471
Date: 2018
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1861-0692
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
6-MINUTE WALK DISTANCE; DISEASE MANAGEMENT REVEAL; IMPORTANT DIFFERENCE; PREDICTIVE-VALUE; HEART-FAILURE; THERAPY; TRIALS; GUIDELINES; DIAGNOSIS; SURVIVALMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18563

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item