Andresen-Streichert, Hilke, Muller, Alexander, Glahn, Alexander, Skopp, Gisela and Sterneck, Martina (2018). Alcohol Biomarkers in Clinical and Forensic Contexts. Dtsch. Arztebl. Int., 115 (18). S. 309 - 321. COLOGNE: DEUTSCHER AERZTE-VERLAG GMBH. ISSN 1866-0452

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Abstract

Background: Biomarkers of alcohol consumption are important not only in forensic contexts, e.g., in child custody proceedings or as documentation of alcohol abstinence after temporary confiscation of a driver's license. They are increasingly being used in clinical medicine as well for verification of abstinence or to rule out the harmful use of alcohol. Methods: This review is based on pertinent publications that were retrieved by a selective literature search in PubMed concerning the direct and indirect alcohol markers discussed here, as well as on the authors' experience in laboratory analysis and clinical medicine. Results: Alongside the direct demonstration of ethanol, the available markers of alcohol consumption include the classic indirect markers carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and mean corpuscular volume (MCV) as well as direct alcohol markers such as ethyl glucuronide (EtG) and ethyl sulfate (EtS) in serum and urine and EtG and fatty acid ethyl esters (FAEE) in hair. Phosphatidylethanol (PEth) is a promising parameter that complements the existing spectrum of tests with high specificity (48-89%) and sensitivity (88-100%). In routine clinical practice, the demonstration of positive alcohol markers often leads patients to admit previously denied alcohol use. This makes it possible to motivate the patient to undergo treatment for alcoholism. Conclusion: The available alcohol biomarkers vary in sensitivity and specificity with respect to the time period over which they indicate alcohol use and the minimum extent of alcohol use that they can detect. The appropriate marker or combination of markers should be chosen in each case according to the particular question that is to be answered by laboratory analysis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Andresen-Streichert, HilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glahn, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skopp, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterneck, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-186653
DOI: 10.3238/arztebl.2018.0309
Journal or Publication Title: Dtsch. Arztebl. Int.
Volume: 115
Number: 18
Page Range: S. 309 - 321
Date: 2018
Publisher: DEUTSCHER AERZTE-VERLAG GMBH
Place of Publication: COLOGNE
ISSN: 1866-0452
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARBOHYDRATE-DEFICIENT TRANSFERRIN; ACID ETHYL-ESTERS; CHROMATOGRAPHY-MASS SPECTROMETRY; CAPILLARY-ZONE-ELECTROPHORESIS; BLOOD SPOT CARDS; PHOSPHATIDYLETHANOL PETH; GLUCURONIDE CONCENTRATION; URINARY-EXCRETION; HAND SANITIZER; LIVER-DISEASEMultiple languages
Medicine, General & InternalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18665

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