Universität zu Köln

Bauer, Dirk, Kasper, Maren, Walscheid, Karoline, Koch, Joerg M., Muether, Philipp S., Kirchhof, Bernd, Heiligenhaus, Arnd and Heinz, Carsten (2018). Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. Front. Immunol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro-and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls. Laser-flare photometry analysis prior to surgery showed no significant differences between JIAUwG or JIAUwoG. Compared with the control group, levels of interleukin-8, matrix metalloproteinase-2, -3, -9, serum amyloid A (SAA), transforming growth factor beta-1, -2, -3 (TGF beta-1, -2, -3), and tumor necrosis factor-alpha in the AH were significantly higher in patients with clinically inactive JIAUwG or JIAUwoG. Samples from JIAwoG patients displayed significantly higher levels of SAA (P < 0.0116) than JIAUwG patients. JIAUwG patients showed an increased level of TGF beta-2 in AH samples compared with JIAUwoG (P < 0.0009). These molecules may contribute to the clinical development of glaucoma in patients with JIAU.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bauer, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasper, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Walscheid, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Joerg M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiligenhaus, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189653
DOI:	10.3389/fimmu.2018.00708
Journal or Publication Title:	Front. Immunol.
Volume:	9
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TGF-BETA; OCULAR HYPERTENSION; INTRAOCULAR-PRESSURE; RHEUMATOID-ARTHRITIS; INCREASED EXPRESSION; TGF-BETA-2; CHILDREN; DISEASE; COMPLICATIONS; INFLAMMATION Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18965