Universität zu Köln

Koehl, Ulrike, Arsenieva, Stanislava, Holzinger, Astrid and Abken, Hinrich (2018). CAR T Cells in Trials: Recent Achievements and Challenges that Remain in the Production of Modified T Cells for Clinical Applications. Hum. Gene Ther., 29 (5). S. 559 - 569. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7422

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Abstract

The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing interest for the treatment of malignant diseases. Early trials with anti-CD19 CAR T cells have achieved spectacular remissions in B-cell leukemia and lymphoma, so far refractory, very recently resulting in the Food and Drug Administration approval of CD19 CAR T cells for therapy. With further applications and increasing numbers of patients, the reproducible manufacture of high-quality clinical-grade CAR T cells is becoming an ever greater challenge. New processing techniques, quality-control mechanisms, and logistic developments are required to meet both medical needs and regulatory restrictions. This paper summarizes the state-of-the-art in manufacturing CAR T cells and the current challenges that need to be overcome to implement this type of cell therapy in the treatment of a variety of malignant diseases and in a greater number of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koehl, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Arsenieva, Stanislava UNSPECIFIED UNSPECIFIED UNSPECIFIED Holzinger, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Abken, Hinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189666
DOI:	10.1089/hum.2017.254
Journal or Publication Title:	Hum. Gene Ther.
Volume:	29
Number:	5
Page Range:	S. 559 - 569
Date:	2018
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-7422
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHIMERIC ANTIGEN RECEPTOR; RETROVIRAL GENE MARKING; B-CELL; NK CELLS; ADOPTIVE THERAPY; MEMORY; MALIGNANCIES; LYMPHOCYTES; EXPRESSION; EXPANSION Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18966