Deger, Moritz ORCID: 0000-0002-2775-2611, Seeholzer, Alexander and Gerstner, Wulfram (2018). Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks. Cereb. Cortex, 28 (4). S. 1396 - 1416. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of spine volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of structural and spike-timing-dependent plasticity that explains the multicontact configuration of synapses in adult neocortical networks under steady-state and lesion-induced conditions. Our plasticity rule with Hebbian and anti-Hebbian terms stabilizes both the postsynaptic firing rate and correlations between the pre- and postsynaptic activity at an active synaptic contact. Contacts appear spontaneously at a low rate and disappear if their strength approaches zero. Many presynaptic neurons compete to make strong synaptic connections onto a postsynaptic neuron, whereas the synaptic contacts of a given presynaptic neuron co-operate via postsynaptic firing. We find that cooperation of multiple synaptic contacts is crucial for stable, long-term synaptic memories. In simulations of a simplified network model of barrel cortex, our plasticity rule reproduces whisker-trimming-induced rewiring of thalamocortical and recurrent synaptic connectivity on realistic time scales.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Deger, MoritzUNSPECIFIEDorcid.org/0000-0002-2775-2611UNSPECIFIED
Seeholzer, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerstner, WulframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-191623
DOI: 10.1093/cercor/bhx339
Journal or Publication Title: Cereb. Cortex
Volume: 28
Number: 4
Page Range: S. 1396 - 1416
Date: 2018
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG-TERM POTENTIATION; NEOCORTEX IN-VIVO; DENDRITIC SPINES; SYNAPTIC PLASTICITY; VISUAL-CORTEX; HOMEOSTATIC PLASTICITY; PYRAMIDAL NEURONS; ADULT CORTEX; CONNECTIVITY; MODELMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19162

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