Universität zu Köln

Veronese, Nicola, Argusti, Alessandra, Canepa, Elisabetta, Polidori, Maria Cristina, Maggi, Stefania, Strandberg, Timo and Pilotto, Alberto (2018). Evaluating the effectiveness and risks of oral anticoagulant treatments in multimorbid frail older subjects with atrial fibrillation using the multidimensional prognostic index: the EURopean study of older subjects with atrial fibrillation-EUROSAF. Eur. Geriatr. Med., 9 (2). S. 149 - 155. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1878-7657

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Abstract

Background Previous studies suggested that a different risk of mortality may influence the oral anticoagulant prescription in older patients with atrial fibrillation (AF). Recently, the Multidimensional Prognostic Index (MPI) demonstrated a high grade of accuracy, calibration and feasibility to predict mortality in hospitalized and community-dwelling older people. Prognostic information, as calculated by the MPI, however, is not included in the decision algorithm of treatments in older patients with AF Purpose The aim of this international multicenter prospective observational study was to evaluate whether a different prognostic profile, as determined by the MPI, is associated with different treatments for AF (no treatment vs oral anticoagulants) and differences in the main outcomes, i.e., mortality, major thromboembolic events and side effects. Materials and methods Older hospitalized patients (age >= 65 years) with non-valvular AF will be consecutively enrolled in an European, cross-national, prospective, observational study. At baseline, functional and clinical information will be collected to calculate the MPI, CHA2DS2-VASc score, HAS-BLED score, pharmacological treatments (and the compliance during follow-up) and main and secondary diagnoses. During the 12-month follow-up period, information on survival, major thromboembolic events and major bleeding will be collected. For these aims, a sample size of 3000 people was deemed as sufficient. Conclusions The EUROSAF study has the main objective of evaluating in a population of hospitalized older subjects with AF the clinical benefit/risk ratio of the oral anticoagulant treatments in terms of mortality, major thromboembolic events and bleeding side-effects, giving important information regarding the appropriate prescription of anticoagulant therapy in this population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Veronese, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Argusti, Alessandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Canepa, Elisabetta UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Maggi, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Strandberg, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilotto, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-191726
DOI:	10.1007/s41999-018-0026-6
Journal or Publication Title:	Eur. Geriatr. Med.
Volume:	9
Number:	2
Page Range:	S. 149 - 155
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1878-7657
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ELDERLY-PATIENTS; RANDOMIZED-TRIALS; STROKE PREVENTION; DECISION-MAKING; MORTALITY; ADULTS; WARFARIN; VALIDATION; CHALLENGES; PEOPLE Multiple languages Geriatrics & Gerontology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19172