Universität zu Köln

Thangarajah, F., Heilmann, J., Malter, W., Kunze, S., Marnitz, S., Mallmann, P., Wenz, F. and Sperk, E. (2018). Breast conserving surgery in combination with intraoperative radiotherapy after previous external beam therapy: an option to avoid mastectomy. Breast Cancer Res. Treat., 168 (3). S. 739 - 745. NEW YORK: SPRINGER. ISSN 1573-7217

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Abstract

Mastectomy is the standard procedure in patients with in-breast tumor recurrence (IBTR) or breast cancer after irradiation of the chest due to Hodgkin's disease. In certain cases a second breast conserving surgery (BCS) in combination with intraoperative radiotherapy (IORT) is possible. To date, data concerning BCS in combination with IORT in pre-irradiated patients are limited. This is the first pooled analysis of this special indication with a mature follow-up of 5 years. Patients with IBTR after external beam radiotherapy (EBRT; treated in two centers) for breast cancer were included. Patients with previous EBRT including the breast tissue due to other diseases were also included. IORT was performed with the Intrabeam (TM)-device using low kV X-rays. Clinical data including outcome for all patients and toxicity for a representative cohort (LENT-SOMA scales) were obtained. Statistical analyses were done including Kaplan-Meier estimates for local recurrence, distant metastasis and overall survival. A total of 41 patients were identified (39 patients with IBTR, 2 with Hodgkin`s disease in previous medical history). Median follow-up was 58 months (range 4-170). No grade 3/4 acute toxicity occurred within 9 weeks. Local recurrence-free survival rate was 89.9% and overall survival was 82.7% at 5 years. Seven patients developed metastasis within the whole follow-up. BCS in combination with IORT in IBTR in pre-irradiated patients is a feasible method to avoid mastectomy with a low risk of side effects and an excellent local control and good overall survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thangarajah, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heilmann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunze, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenz, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sperk, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192155
DOI:	10.1007/s10549-017-4657-y
Journal or Publication Title:	Breast Cancer Res. Treat.
Volume:	168
Number:	3
Page Range:	S. 739 - 745
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7217
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGIONAL RECURRENCE; SALVAGE MASTECTOMY; CANCER; TARGIT; WOMEN Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19215