Universität zu Köln

Powers, John H., III, Bacci, Elizabeth D., Leidy, Nancy K., Poona, Jiat-Ling, Stringer, Sonja, Memoli, Matthew J., Han, Alison, Fairchok, Mary P., Coles, Christian, Owens, Jackie, Chen, Wei-Ju, Arnold, John C., Danaher, Patrick J., Lalani, Tahaniyat, Burgess, Timothy H., Millar, Eugene V., Ridore, Michelande, Hernandez, Andres, Rodriguez-Zulueta, Patricia, Ortega-Gallegos, Hilda, Galindo-Fraga, Arturo ORCID: 0000-0002-2818-1160, Ruiz-Palacios, Guillermo M., Pett, Sarah, Fischer, William, Gillor, Daniel, Moreno Macias, Laura, DuVal, Anna, Rothman, Richard, Dugas, Andrea and Lourdes Guerrerom, M. (2018). Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI). PLoS One, 13 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza. Objectives This study tested the reliability, validity, and responsiveness of FLU-PRO scores in adults with influenza-like illness (ILI). Methods Data from the prospective, observational study used to develop and test the FLU-PRO in influenza virus positive patients were analyzed. Adults (>= 18 years) presenting with influenza symptoms in outpatient settings in the US, UK, Mexico, and South America were enrolled, tested for influenza virus, and asked to complete the 37-item draft FLU-PRO daily for up to 14-days. Analyses were performed on data from patients testing negative. Reliability of the final, 32-item FLU-PRO was estimated using Cronbach's alpha (a; Day 1) and intraclass correlation coefficients (ICC; 2-day reproducibility). Convergent and known-groups validity were assessed using patient global assessments of influenza severity (PGA). Patient report of return to usual health was used to assess responsiveness (Day 1-7). Results The analytical sample included 220 ILI patients (mean age = 39.3, 64.1% female, 88.6% white). Sixty-one (28%) were hospitalized at some point in their illness. Internal consistency reliability (a) of FLU-PRO Total score was 0.90 and ranged from 0.72-0.86 for domain scores. Reproducibility (Day 1-2) was 0.64 for Total, ranging from 0.46-0.78 for domain scores. Day 1 FLU-PRO scores correlated (>= 0.30) with the PGA (except Gastrointestinal) and were significantly different across PGA severity groups (Total: F = 81.7, p<0.001; sub scales: F = 6.9-62.2; p<0.01). Mean score improvements Day 1-7 were significantly greater in patients reporting return to usual health compared with those who did not (p<0.05, Total and subscales, except Gastrointestinal and Eyes). Conclusions Results suggest FLU-PRO scores are reliable, valid, and responsive in adults with influenza-like illness.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Powers, John H., III UNSPECIFIED UNSPECIFIED UNSPECIFIED Bacci, Elizabeth D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leidy, Nancy K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Poona, Jiat-Ling UNSPECIFIED UNSPECIFIED UNSPECIFIED Stringer, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Memoli, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Alison UNSPECIFIED UNSPECIFIED UNSPECIFIED Fairchok, Mary P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coles, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Owens, Jackie UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Wei-Ju UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnold, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Danaher, Patrick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lalani, Tahaniyat UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgess, Timothy H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Millar, Eugene V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ridore, Michelande UNSPECIFIED UNSPECIFIED UNSPECIFIED Hernandez, Andres UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez-Zulueta, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortega-Gallegos, Hilda UNSPECIFIED UNSPECIFIED UNSPECIFIED Galindo-Fraga, Arturo UNSPECIFIED orcid.org/0000-0002-2818-1160 UNSPECIFIED Ruiz-Palacios, Guillermo M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pett, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, William UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillor, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Moreno Macias, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED DuVal, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothman, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Dugas, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Lourdes Guerrerom, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192514
DOI:	10.1371/journal.pone.0194180
Journal or Publication Title:	PLoS One
Volume:	13
Number:	3
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRUSES; INSTRUMENT; SYMPTOMS; VALIDITY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19251